CCP1100-5mg Beta-Amyloid (1-42), Human

Search for all "Beta-Amyloid (1-42), Human"

Properties for Beta-Amyloid (1-42), Human

Product Category Synthetic Peptides
Quantity 5 mg
Molecular weight 4514.14
Source Synthetic
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Cohesion Biosciences Ltd.

Datasheet Extract

Purity > 95 %
Background A�� 1-42 42-residue fragment of amyloid precursor protein has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. A�� 1-42 readily forms neurotoxic oligomers at physiological pH. The sequence corresponds to the human bovine canine feline ovine guinea pig and rabbit A��42 peptide. The peptide has been used to detect amyloid ��-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of A�� 1-42 monomers and protofibrils please see the papers of Jan Hartley and Lashuel and of Broersen and colleagues. The recent findings of Ryan et al. indicate that 10% ammonia disaggregates A��42 more efficiently than HFIP.
Storage Shipped at 4°C. Store at -20°C for one year.
Peptide to Beta-Amyloid (1-42), Human
CAS Number: 107761-42-2
Molecular Formula: C203H311N55O60S
Chemical Structure: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Lyophilized powder
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