CCP1720-10mg [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P

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Properties for [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P

Product Category Synthetic Peptides
Quantity 10 mg
Molecular weight 1516.87
Source Synthetic
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Cohesion Biosciences Ltd.

Datasheet Extract

Purity > 95 %
Background [D-Arg1; D-Phe5; D-Trp7; 9; Leu11]-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC?? = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control; inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity.
Storage Shipped at 4°C. Store at -20°C for one year.
Peptide to [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P
CAS Number: 96736-12-8
Molecular Formula: C79H109N19O12
Chemical Structure: D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
Lyophilized powder
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