CCP1386-1mg Prion Peptide (106-126), Human

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Properties for Prion Peptide (106-126), Human

Product Category Synthetic Peptides
Quantity 1 mg
Molecular weight 1912.28
Source Synthetic
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Cohesion Biosciences Ltd.

Datasheet Extract

Purity > 95 %
Background An altered form of the large cellular prion protein accumulates in the CNS of patients with neurodegenerative disorders and its protease-resistant core aggregates extracellularly into amyloid fibrils. This process is accompanied by nerve cell loss. The 21-peptide KTNMKHMAGAAAAGAVVGGLG is used as a model to investigate neurodegeneration in prion diseases. Prion Protein (106-126) forms fibrils in vitro and causes apoptotic cell death in neuron culture. Its neurotoxicity depends on the presence of microglia and is induced by microglia. It could be demonstrated that KTNMKHMAGAAAAGAVVGGLG is able to bind to DNA a circumstance which led to the assumption that the integral protein could also bind to DNA under appropriate solution conditions.
Storage Shipped at 4°C. Store at -20°C for one year.
Peptide to Prion Peptide (106-126), Human
CAS Number: 148439-49-0
Molecular Formula: C80H138N26O24S2
Chemical Structure: H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH
Lyophilized powder
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