11-beta HSD2 / HSD11B2 antibody

Principal name

11-beta HSD2 / HSD11B2 antibody

Alternative names for 11-beta HSD2 / HSD11B2 antibody

11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

SwissProt ID

O77667 (Bovin), P50168 (Sheep), P50233 (Rat), P51661 (Mouse), P51976 (Rabit), P80365 (Human)

Gene ID

3291 (HSD11B2), 15484 (Hsd11b2), 25117

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Eq (Equine), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Sh (Sheep), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of 11-beta HSD2 / HSD11B2 antibody

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

General readings

Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010)
Ni, X.T., et al. Placenta 30(12):1023-1028(2009)
Mericq, V., et al. Eur. J. Endocrinol. 161(3):419-425(2009)
Stark, M.J., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 (2), R510-R514 (2009)
Lepenies, J., et al. Clin. Exp. Hypertens. 31(4):376-379(2009)

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

11-beta HSD2 / HSD11B2 antibody

  Rabbit Polyclonal Anti-HSD11B2 Antibody  
WB Suggested Anti-HSD11B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

11-beta HSD2 / HSD11B2 antibody

  Rabbit Polyclonal Anti-HSD11B2 Antibody  
Gel: 8%SDS-PAGE,Lysate: 40 ug,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: (HSD11B2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

11-beta HSD2 / HSD11B2 (25-40) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bov, Bt, Elephant, Eq, Hu, Mky, Ms, Por, Prim, Rb, Rt, Sh P, WB
50 µg / €470.00
  Acris Antibodies GmbH

11-beta HSD2 / HSD11B2 (Center) antibody

HSD11B2 Antibody AP52107PU-N IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HSD11B2 - human gene knockout kit via CRISPR

HSD11B2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HSD11B2 - human gene knockout kit via CRISPR

HSD11B2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD11B2 - human gene knockout kit via CRISPR

HSD11B2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD11B2 - human gene knockout kit via CRISPR

HSD11B2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hsd11b2 - mouse gene knockout kit via CRISPR

Hsd11b2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hsd11b2 - mouse gene knockout kit via CRISPR

Hsd11b2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hsd11b2 - mouse gene knockout kit via CRISPR

Hsd11b2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hsd11b2 - mouse gene knockout kit via CRISPR

Hsd11b2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

11-beta HSD2 / HSD11B2

  Recombinant protein of human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)  
11-beta HSD2 / HSD11B2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

HSD11B2 overexpression lysate

HSD11B2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HSD11B2 (mGFP-tagged) - Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), 200 uL, >10^7 TU/mL

Lenti ORF particles, HSD11B2 (mGFP-tagged) - Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, HSD11B2 (Myc-DDK tagged) - Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, HSD11B2 (Myc-DDK tagged) - Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hsd11b2 (GFP-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd11b2 (GFP-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hsd11b2 (Myc-DDK-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd11b2 (Myc-DDK-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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