11-beta HSD2 / HSD11B2 antibody

Principal name

11-beta HSD2 / HSD11B2 antibody

Alternative names for 11-beta HSD2 / HSD11B2 antibody

11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

SwissProt ID

O77667 (Bovin), P50168 (Sheep), P50233 (Rat), P51661 (Mouse), P51976 (Rabit), P80365 (Human)

Gene ID

3291 (HSD11B2)

Available reactivities

Hu (Human), Mky (Monkey), Rt (Rat), Ms (Mouse), Sh (Sheep), Bov (Bovine), Por (Porcine), Rb (Rabbit), Chimp (Chimpanzee)

Available hosts

Chicken, Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F)

Background of 11-beta HSD2 / HSD11B2 antibody

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

General readings

1. Mune,T., Morita,H., Suzuki,T., Takahashi,Y., Isomura,Y., Tanahashi,T., Daido,H., Yamakita,N., Deguchi,T., Sasano,H.,, et al.
Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas
2. Kajantie,E., Dunkel,L., Turpeinen,U., Stenman,U.H., Wood,P.J., Nuutila,M. and Andersson,S.
Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants
3. Alfaidy,N., Gupta,S., DeMarco,C., Caniggia,I. and Challis,J.R., et al.
Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
4. Hardy,D.B. and Yang,K., et al.
The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia
5. Stauffer,A.T., Rochat,M.K., Dick,B., Frey,F.J. and Odermatt,A., et al.
Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor
6. , Albiston A.L., Obeyesekere V.R., Smith R.E., Krozowski Z.S.
Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme.
7. , Agarwal A.K., Rogerson F.M., Mune T., White P.C.
Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase.
8. , Brown R.W., Chapman K.E., Kotelevtsev Y., Yau J.L., Lindsay R.S., Brett L., Leckie C., Murad P., Lyons V., Mullins J.J., et al.
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.
9. , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10. , Amin H.K., Hoeppner W.
Human hydroxysteroid dehydrogenase type 2 HSD11B2.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

11-beta HSD2 / HSD11B2 antibody

Immunohistochemical of  paraffin-embedded human kidney using 14192-1-AP(HSD11B2 antibody) at dilution of 1:50 (under 10x lens) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.15 ml / €285.00
  Proteintech Group, Inc.

11-beta HSD2 / HSD11B2 (25-40) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

11-beta HSD2 / HSD11B2 (Center) antibody

HSD11B2 Antibody AP52107PU-N IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €360.00
  Acris Antibodies GmbH

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Chicken Aff - Purified Chimp, Hu, Rt WB

Regular Price: 50 µg / €500.00

Special Price: 50 µg / €425.00

  GeneTex Inc.

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit Aff - Purified Sh C, WB

Regular Price: 0.1 ml / €350.00

Special Price: 0.1 ml / €297.50

  GeneTex Inc.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab polyclonal antibody. Western Blot analysis of HSD11B2 expression in human colon. Mouse Serum Hu E(detection), WB
50 µl / €360.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab polyclonal antibody. Western Blot analysis of HSD11B2 expression in human colon. Mouse Purified Hu E(detection), WB
50 µg / €360.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

Human Muscle; WB Suggested Anti-HSD11B2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Muscle; HSD11B2 antibody - N-terminal region (ARP41372_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

11-beta HSD2 / HSD11B2 antibody

Formalin-fixed and paraffin embedded rat kidney labeled with Anti- HSD11B2 Polyclonal Antibody, Unconjugated (bs-3618R) at 1:200 followed by conjugation to the secondary antibody and DAB staining Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €240.00
  Bioss, Inc.

11-beta HSD2 / HSD11B2 antibody

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-HSD11B2 ) Chicken Aff - Purified Hu, Mky, Rt WB
50 µg / €520.00
  Novus Biologicals Inc.

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit IgG Hu, Ms, Rt P, WB
50 µg / €480.00
  Novus Biologicals Inc.

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €370.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €370.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HSD11B2 Lysate

Western Blot: HSD11B2 Lysate [NBL1-11721] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for HSD11B2.  
0.1 mg / €400.00
  Novus Biologicals Inc.

20 Item(s)

per page
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