11-beta HSD2 / HSD11B2 antibody

Principal name

11-beta HSD2 / HSD11B2 antibody

Alternative names for 11-beta HSD2 / HSD11B2 antibody

11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

SwissProt ID

O77667 (Bovin), P50168 (Sheep), P50233 (Rat), P51661 (Mouse), P51976 (Rabit), P80365 (Human)

Gene ID

3291 (HSD11B2), 15484 (Hsd11b2), 25117

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Eq (Equine), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Sh (Sheep), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of 11-beta HSD2 / HSD11B2 antibody

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

General readings

Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010)
Ni, X.T., et al. Placenta 30(12):1023-1028(2009)
Mericq, V., et al. Eur. J. Endocrinol. 161(3):419-425(2009)
Stark, M.J., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 (2), R510-R514 (2009)
Lepenies, J., et al. Clin. Exp. Hypertens. 31(4):376-379(2009)

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

11-beta HSD2 / HSD11B2 antibody

WB Suggested Anti-HSD11B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

11-beta HSD2 / HSD11B2 antibody

Gel: 8%SDS-PAGE,Lysate: 40 ug,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: (HSD11B2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

11-beta HSD2 / HSD11B2 (25-40) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bov, Bt, Elephant, Eq, Hu, Mky, Ms, Por, Prim, Rb, Rt, Sh P, WB
50 µg / €470.00
  Acris Antibodies GmbH

11-beta HSD2 / HSD11B2 (Center) antibody

HSD11B2 Antibody AP52107PU-N IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab polyclonal antibody. Western Blot analysis of HSD11B2 expression in human colon. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab polyclonal antibody. Western Blot analysis of HSD11B2 expression in human colon. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2 antibody

Human Muscle; WB Suggested Anti-HSD11B2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Muscle; HSD11B2 antibody - N-terminal region (ARP41372_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

HSD11B2 overexpression lysate

HSD11B2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hsd11b2 (GFP-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd11b2 (GFP-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hsd11b2 (Myc-DDK-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd11b2 (Myc-DDK-tagged ORF) - Rat hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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