14-3-3 protein eta antibody

Principal name

14-3-3 protein eta antibody

Alternative names for 14-3-3 protein eta antibody

Protein AS1, YWHAH, YWHA1

Selected pictures

14-3-3 protein eta antibody - H00007533-M04
H00007533-M04 - Detection limit for recombinant GST tagged YWHAH is approximately 0.1ng/ml as a capture antibody.
14-3-3 protein eta antibody - H00007533-A01
H00007533-A01 - YWHAH polyclonal antibody (A01), Lot # 060524JCS1 Western Blot analysis of YWHAH expression in SJCRH30 ( Cat # L027V1 ).

SwissProt ID

P68509 (Bovin), P68510 (Mouse), P68511 (Rat), Q04917 (Human)

Gene ID

7533 (YWHAH)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Sh (Sheep), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C)

Background of 14-3-3 protein eta antibody

14-3-3 eta is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.
14-3-3 eta is expressed principally in the brain although it is expressed at low levels in other tissues. The protein binds alphasynuclein, forming part of lewy bodies in parkinsons disease and has been linked to earlyonset schizophrenia. The eta isoform binds both gremlin 1, which is overexpressed in human cancers, and the DAL1/Protein 4.1B tumour suppressor. Furthermore the glucocortcoid receptor is positively regulated by 14-3-3eta.
AHP1046 may not react with recombinant proteins that are not Nacetylated.

General readings

Shigeto Sato., et al. (2006), EMBO. 25, 211-221.
Chen J., et al. (2007), J Neurosci Res. 85(8):1724-33.

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