14-3-3 protein theta antibody

Principal name

14-3-3 protein theta antibody

Alternative names for 14-3-3 protein theta antibody

14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1

SwissProt ID

P27348 (Human)

Gene ID

10971 (YWHAQ)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Rb (Rabbit), Sh (Sheep), Can (Canine), Ze (Zebrafish), African clawed frog, Por (Porcine), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C)

Background of 14-3-3 protein theta antibody

At least seven isoforms comprise the highly conserved 14-3-3 family of homo-and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. These multifunctional proteins bind and modulate the function of a wide array of cellular proteins. They exist mainly as dimers with a monomeric molecular mass of approximately 30 kDa and have an acidic isoelectric point of 4.5-5. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with bad, prevents apoptosis.3 14-3-3 plays a dual role in Raf-1 activation. It helps to keep Raf-1 in an inactive state by binding to phophoserine-259 and the cysteine-rich domain (DRD). Interactions of 14-3-3 at the phosphoserine-621 may be required for Raf-1 activation and may function as an essential cofactor for Raf-1 kinase activity.3 Other proteins that have been shown to bind 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, middle-T antigen, KSR, IGF-1 receptor, etc.3 Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases. The theta or tau isoform was initially isolated from T cells.1 It

General readings

Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M.
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle.
Diabetes. 2007 Jun;56(6):1608-14. Epub 2007 Mar 16.
PMID: 17369524

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

14-3-3 protein theta antibody

TA303297 (0.03µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

14-3-3 protein theta antibody

Human kidney; YWHAQ antibody - N-terminal region (AVARP02062_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

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