14-3-3 protein theta antibody

Principal name

14-3-3 protein theta antibody

Alternative names for 14-3-3 protein theta antibody

14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1

SwissProt ID

P27348 (Human)

Gene ID

10971 (YWHAQ)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Sh (Sheep), Can (Canine), Ze (Zebrafish), African clawed frog, Por (Porcine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunoprecipitation (IP), Frozen Sections (C)

Background of 14-3-3 protein theta antibody

14-3-3 theta is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple cell signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preferences for it’s different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.
14-3-3 tau/theta is primarily expressed in Tcells although it occurs at lower levels in the brain, heart, pancreas placenta and kidneys. It plays a role in cell cycle progression via interaction with p27(Kip1). Along with COPI, the theta isoform binds the GB1 RSR sequence involved in protein trafficking. The isoform forms a complex with Hsp60 and cellular prion protein which may be involved in prion diseases. Elevated levels of 14-3-3 tau/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau/theta also binds BCR/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor.

General readings

Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M.
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle.
Diabetes. 2007 Jun;56(6):1608-14. Epub 2007 Mar 16.
PMID: 17369524

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

14-3-3 protein theta antibody

  Goat Polyclonal Antibody against YWHAQ  
TA303297 (0.03µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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