14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

Selected pictures

14-3-3 protein zeta/delta antibody - A0001-1 14-3-3 protein zeta/delta
A0001-1 14-3-3 protein zeta/delta - Immunofluorescence analysis of HeLa cells treated with PMA 125ng/ml 30', using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide.
14-3-3 protein zeta/delta antibody - A0001-1 14-3-3 protein zeta/delta
A0001-1 14-3-3 protein zeta/delta - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide.

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ), 25578 (Ywhaz)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Fe (Feline), Mky (Monkey), Por (Porcine), Can (Canine), Op (Opossum), Ze (Zebrafish), African clawed frog, Sh (Sheep), Dros (Drosophila)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303.
2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172.
3. Wang, Z. et al. (2011) The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3ß and e are independent prognostic factors for these tumors.
PLoS One. 6: e24843.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AM20301PU-N

14-3-3 protein zeta/delta (222-240) antibody

Western blot analysis of 14-3-3 zeta using AM20301PU-N 14-3-3 zeta antibody at 1 µg/ml. HRP Goat anti-Mouse Ig secondary antibody and PicoTect ECL substrate solution were used for this test. 
A) Human brain lysate 
B) Mouse brain lysate
C) Rat brain lysate 
D) recombinant 14-3-3 zeta protein Mouse IgG1 IMG2E11 Purified Bov, Chk, Fe, Hu, Mky, Ms, Por, Rt P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH
AP21526PU-N

14-3-3 protein zeta/delta (50-100) antibody

Western blot analysis of 14-3-3 zeta in human brain lysate in the 1) absence, 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysate using AP21526PU-N at 4 µg/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rabbit Purified Bov, Can, Hu, Mky, Ms, Op, Por P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH
ARP48046_T100

14-3-3 protein zeta/delta antibody

Human HepG2; WB Suggested Anti-YWHAZ Antibody Titration: 5.0ug/ml. Positive Control: HepG2 cell lysate; YWHAZ antibody - C-terminal region (ARP48046_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Dros, Hu, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology
bs-9654R

14-3-3 protein zeta/delta antibody

Antigen: bs-9654P, 2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Rabbit Anti-Goat IgG(bs-0294R-HRP) at 1: 5000; TMB stainingRead the data in Microplate Reader by 450nm. Rabbit IgG Aff - Purified Bov, Hu, Ms, Por, Rt E, ICC/IF, P, WB
0.1 ml / €240.00
  Bioss, Inc.
CPA2243-30ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.
CPA2243-100ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.
CPA2243-200ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.
CPA2244-30ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in HeLa (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.
CPA2244-100ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in HeLa (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.
CPA2244-200ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in HeLa (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.
CPA2245-30ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.
CPA2245-100ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.
CPA2245-200ul

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

13 Item(s)

per page
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