14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ), 25578 (Ywhaz)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Sh (Sheep), Can (Canine), Dros (Drosophila), Por (Porcine), African clawed frog, Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303.
2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172.
3. Wang, Z. et al. (2011) The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3ß and e are independent prognostic factors for these tumors.
PLoS One. 6: e24843.

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

14-3-3 protein zeta/delta antibody

Human HepG2; WB Suggested Anti-YWHAZ Antibody Titration: 5.0ug/ml. Positive Control: HepG2 cell lysate; YWHAZ antibody - C-terminal region (ARP48046_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Dros, Hu, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

14-3-3 protein zeta/delta pSer58 antibody

Immunohistochemical analysis of 14-3-3 zeta (pS58) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta pSer58 antibody

Immunohistochemical analysis of 14-3-3 zeta (pS58) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta pSer58 antibody

Immunohistochemical analysis of 14-3-3 zeta (pS58) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Western blot analysis of 14-3-3 zeta expression in KNRK (A); NIH3T3 (B); C4 (C); EOC20 (D); CTLL2 (E) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

13 Item(s)

per page
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