14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

Selected pictures

14-3-3 protein zeta/delta antibody - A0001-1 14-3-3 protein zeta/delta
A0001-1 14-3-3 protein zeta/delta - Immunofluorescence analysis of HeLa cells treated with PMA 125ng/ml 30', using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide.
14-3-3 protein zeta/delta antibody - A0001-1 14-3-3 protein zeta/delta
A0001-1 14-3-3 protein zeta/delta - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide.

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ), 25578 (Ywhaz)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Fe (Feline), Mky (Monkey), Por (Porcine), Can (Canine), Op (Opossum), Ze (Zebrafish), African clawed frog, Sh (Sheep), Dros (Drosophila)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303.
2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172.
3. Wang, Z. et al. (2011) The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3ß and e are independent prognostic factors for these tumors.
PLoS One. 6: e24843.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AP02457PU-N

14-3-3 protein zeta/delta pSer58 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 zeta (Phospho-Ser58) antibody AP02457PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH
AP02457PU-S

14-3-3 protein zeta/delta pSer58 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 zeta (Phospho-Ser58) antibody AP02457PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH
AP07437PU-N

14-3-3 protein zeta/delta pSer58 antibody

Lung, respiratory epithelium: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH
A0001-1

14-3-3 protein zeta/delta pSer58 antibody

Immunofluorescence analysis of HeLa cells treated with PMA 125ng/ml 30', using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech
A0001-2

14-3-3 protein zeta/delta pSer58 antibody

Immunofluorescence analysis of HeLa cells treated with PMA 125ng/ml 30', using 14-3-3 zeta (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech
CPA2243-30ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.
CPA2243-100ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.
CPA2243-200ul

14-3-3 protein zeta/delta pSer58 antibody

Western blot analysis of 14-3-3 zeta (pS58) expression in MCF7 (A); A549 (B); SP2/0 (C); rat liver (D); NIH3T3 (E); A431 (F) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt, Sh, Ze ICC/IF, IP, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.
NB100-81766

14-3-3 protein zeta/delta pSer58 antibody

Immunohistochemistry: 14-3-3 zeta Phosphospecific Antibody [NB100-81766] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 æ (Phospho-Ser58) antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Novus Biologicals Inc.

9 Item(s)

per page
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