14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Sh (Sheep), Can (Canine), Dros (Drosophila), Por (Porcine), African clawed frog, Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303.
2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172.
3. Wang, Z. et al. (2011) The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3ß and e are independent prognostic factors for these tumors.
PLoS One. 6: e24843.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

14-3-3 protein zeta/delta (N-term acetylated) antibody

Western blots of 14-3-3 isoforms in HEK293 cell extracts using 14-3-3 antibodies.
Lane 1: anti-gamma 14-3-3 (AP05567SU-N)
Lane 2: anti-zeta 14-3-3 (AP05572SU-N)
Lane 3: anti-C-epsilon-14-3-3 (AP05565SU-N)
Lane 4: anti-N-epsilon-14-3-3 (AP05568SU-N)
Lane 5: anti-eta 14-3-3. (AP05566SU-N)

The 14-3-3 isoforms run at 30kDa except epsilon 14-3-3 Rabbit IgG Serum Bov, Chk, Hu, Ms, Rt, Sh E, P, WB
0.1 ml / €470.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta pSer58 antibody

Lung, respiratory epithelium: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with PLD1 antibody (N-term) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €380.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta antibody

Immunohistochemistry (IHC) analyzes of 14-3-3 ζ (pVal52) antibody (Cat.-No AP20192PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta antibody

Immunohistochemistry (IHC) analyzes of 14-3-3 zeta antibody (Cat.-No AP20468PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta pSer184 antibody

14-3-3 protein zeta/delta Rabbit Serum Hu, Ms, Rt E, P, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta pThr232 antibody

Western blot analysis of extracts from Jurkat cells treated with UV using Phospho-14-3-3 zeta/ delta (Thr232) antibody AP55906PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta pThr232 antibody

Western blot analysis of extracts from Jurkat cells treated with UV using Phospho-14-3-3 zeta/ delta (Thr232) antibody AP55906PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

14-3-3 protein zeta/delta antibody

Western blots of 14-3-3 isoforms in HEK293 cell extracts using GeneTex antibodies.
Lane 1 = anti-gamma 14-3-3 (GTX110629)
Lane 2 = anti-zeta 14-3-3 (GTX42902)
Lane 3 = anti-C-epsilon-14-3-3 (GTX42905)
Lane 4 = anti-N-epsilon-14-3-3 (GTX42906)
Lane 5 = anti-eta 14-3-3. (GTX42904)
The 14-3-3 isoforms run at 30kDa except epsilon 14-3-3 which migrates at 33kDa Rabbit Bov, Chk, Hu, Ms, Rb, Rt E, P, WB
0.1 ml / €510.00
  GeneTex Inc.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3 zeta Antibody (GTX50519) (left) or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt C, WB
0.1 ml / €370.00
  GeneTex Inc.

14-3-3 protein zeta/delta antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3 zeta (Phospho-Ser58) Antibody (GTX50712) (left) or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €370.00
  GeneTex Inc.

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €430.00
  GeneTex Inc.

14-3-3 protein zeta/delta antibody

Sample (30 ug of whole cell lysate)  A: NIH-3T3   B: JC   12% SDS PAGE  GTX114140 diluted at 1:1000 Rabbit IgG Aff - Purified Ms WB
0.1 ml / €350.00
  GeneTex Inc.

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

14-3-3 protein zeta/delta antibody

Western Blot analysis of YWHAZ expression in transfected 293T cell line by YWHAZ monoclonal antibody (M04), clone 1B3.

Lane 1: YWHAZ transfected lysate(27.7 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 1B3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Mouse IgG2a 5E8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

14-3-3 protein zeta/delta antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with YWHAZ polyclonal antibody ( Cat # PAB4027 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

14-3-3 protein zeta/delta antibody

Western blot analysis of YWHAZ polyclonal antibody ( Cat # PAB4028 ) in A-375 cell lysate ( 35 µg/lane ) . YWHAZ ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

14-3-3 protein zeta/delta antibody

Immunohistochemical staining of YWHAZ on formalin fixed, paraffin embedded human breast carcinoma with YWHAZ polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

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