17-beta-HSD1 / HSD17B1 antibody

Principal name

17-beta-HSD1 / HSD17B1 antibody

Alternative names for 17-beta-HSD1 / HSD17B1 antibody

20 alpha-hydroxysteroid dehydrogenase, 20-alpha HSD, 17E2DH, EDH17B1, EDH17B2, EDHB17, E17KSR, Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, Placental 17-beta-hydroxysteroid dehydrogenase

SwissProt ID

P14061 (Human), P51656 (Mouse), P51657 (Rat)

Gene ID

3292 (HSD17B1), 25322 (Hsd17b1), 15485

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of 17-beta-HSD1 / HSD17B1 antibody

HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I),also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase,is an enzyme that is responsible for the interconversion of estrone (E1) and estradiol (E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42 (81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42 (43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.

General readings

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

17-beta-HSD1 / HSD17B1 antibody

WB Suggested Anti-HSD17B1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

17-beta-HSD1 / HSD17B1 antibody

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human placenta tissue, Primary antibody: (HSD17B1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

17-beta-HSD1 / HSD17B1 (C-term) antibody

Western blot analysis of HSD17B1 Antibody (C-term) Cat.-No AP52108PU-N in SK-BR-3 cell line lysates (35ug/lane). This demonstrates the HSD17B1 antibody detected the HSD17B1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1 antibody

Immunoperoxidase of monoclonal antibody to HSD17B1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG1 2E5 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1 antibody

HSD17B1 monoclonal antibody (M03), clone 2E5 Western Blot analysis of HSD17B1 expression in Jurkat ( Cat # L017V1 ). Mouse IgG1 2E5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1 antibody

Human Kidney; Rabbit Anti-HSD17B1 Antibody. Catalog Number: ARP41727. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; HSD17B1 antibody - N-terminal region (ARP41727_P050) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

HSD17B1 - human gene knockout kit via CRISPR

HSD17B1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HSD17B1 - human gene knockout kit via CRISPR

HSD17B1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD17B1 - human gene knockout kit via CRISPR

HSD17B1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD17B1 - human gene knockout kit via CRISPR

HSD17B1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HSD17B1 (mGFP-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL

Lenti ORF particles, HSD17B1 (mGFP-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, HSD17B1 (Myc-DDK-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL

Lenti ORF particles, HSD17B1 (Myc-DDK-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hsd17b1 (GFP-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd17b1 (GFP-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hsd17b1 (Myc-DDK-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hsd17b1 (Myc-DDK-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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