17-beta-HSD1 / HSD17B1 antibody
Principal name
17-beta-HSD1 / HSD17B1 antibody
Alternative names for 17-beta-HSD1 / HSD17B1 antibody
20 alpha-hydroxysteroid dehydrogenase, 20-alpha HSD, 17E2DH, EDH17B1, EDH17B2, EDHB17, E17KSR, Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, Placental 17-beta-hydroxysteroid dehydrogenase
Ncbi ID
9606, NP_000404, NP_036983.1, NP_000404.2, NP_034605.1, NM_010475, NM_012851, NM_000413
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of 17-beta-HSD1 / HSD17B1 antibody
HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I),also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase,is an enzyme that is responsible for the interconversion of estrone (E1) and estradiol (E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42 (81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42 (43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.
General readings
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA346185 | 17-beta-HSD1 / HSD17B1 antibody |
||||||
| Rabbit Polyclonal Anti-HSD17B1 Antibody | |||||||
 |
Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt | P, WB |
50 µg /
€360.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
|||||||
| TA351268 | 17-beta-HSD1 / HSD17B1 antibody |
||||||
| Rabbit Polyclonal Anti-HSD17B1 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| +2 additional images |
|||||||
| AP52108PU-N | 17-beta-HSD1 / HSD17B1 (C-term) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu | WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN211135 | HSD17B1 - human gene knockout kit via CRISPR |
||
 |
Human | GFP-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN211135BN | HSD17B1 - human gene knockout kit via CRISPR |
||
|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN211135LP | HSD17B1 - human gene knockout kit via CRISPR |
||
|
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN211135RB | HSD17B1 - human gene knockout kit via CRISPR |
||
|
Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307965 | Hsd17b1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | GFP-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307965BN | Hsd17b1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307965LP | Hsd17b1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN307965RB | Hsd17b1 - mouse gene knockout kit via CRISPR |
||
|
Mouse | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| AR50925PU-N | 17-beta-HSD1 / HSD17B1 (1-328, His-tag) |
||||
 |
Human | Purified | > 90 % by SDS - PAGE | E. coli |
0.25 mg /
€730.00
|
| Acris Antibodies GmbH | |||||
| AR50925PU-S | 17-beta-HSD1 / HSD17B1 (1-328, His-tag) |
||||
|
Human | Purified | > 90 % by SDS - PAGE | E. coli |
50 µg /
€300.00
|
| Acris Antibodies GmbH | |||||
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC211135L2V | Lenti ORF particles, HSD17B1 (mGFP-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€989.00
|
|
| OriGene Technologies, Inc. | ||
| RC211135L1V | Lenti ORF particles, HSD17B1 (Myc-DDK-tagged)-Human hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€886.00
|
|
| OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR222239L2V | Lenti ORF particles, Hsd17b1 (GFP-tagged) - Mouse hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€907.00
|
|
| OriGene Technologies, Inc. | ||
| MR222239L1V | Lenti ORF particles, Hsd17b1 (Myc-DDK-tagged) - Mouse hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€804.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR201524L2V | Lenti ORF particles, Hsd17b1 (GFP-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€907.00
|
|
| OriGene Technologies, Inc. | ||
| RR201524L1V | Lenti ORF particles, Hsd17b1 (Myc-DDK-tagged ORF) - Rat hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€804.00
|
|
| OriGene Technologies, Inc. | ||
