17-beta-HSD1 / HSD17B1 antibody

Principal name

17-beta-HSD1 / HSD17B1 antibody

Alternative names for 17-beta-HSD1 / HSD17B1 antibody

20 alpha-hydroxysteroid dehydrogenase, 20-alpha HSD, 17E2DH, EDH17B1, EDH17B2, EDHB17, E17KSR, Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, Placental 17-beta-hydroxysteroid dehydrogenase

SwissProt ID

P14061 (Human), P51656 (Mouse), P51657 (Rat)

Gene ID

3292 (HSD17B1), 25322 (Hsd17b1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of 17-beta-HSD1 / HSD17B1 antibody

The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)

General readings

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

17-beta-HSD1 / HSD17B1 (C-term) antibody

Western blot analysis of HSD17B1 Antibody (C-term) Cat.-No AP52108PU-N in SK-BR-3 cell line lysates (35ug/lane). This demonstrates the HSD17B1 antibody detected the HSD17B1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1 antibody

Immunoperoxidase of monoclonal antibody to HSD17B1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG1 2E5 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1 antibody

HSD17B1 monoclonal antibody (M03), clone 2E5 Western Blot analysis of HSD17B1 expression in Jurkat ( Cat # L017V1 ). Mouse IgG1 2E5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1 antibody

Human Kidney; Rabbit Anti-HSD17B1 Antibody. Catalog Number: ARP41727. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; HSD17B1 antibody - N-terminal region (ARP41727_P050) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

17-beta-HSD1 / HSD17B1 antibody

17-beta-HSD1 / HSD17B1 Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

17-beta-HSD1 / HSD17B1 (C-term) antibody

Immunohistochemistry: HSD17B1 (C-term) Antibody (EP1682Y) [NB110-57057] - Immunohistochemical staining of paraffin-embedded human placenta using anti-HSD17B1 (cat. #110-57057). Rabbit IgG EP1682Y Purified Hu F, ICC/IF, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

17-beta-HSD1 / HSD17B1 antibody

Western Blot: HSD17B1 Antibody [NBP1-56295] - This Anti-HSD17B1 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

17-beta-HSD1 / HSD17B1 antibody

Immunohistochemistry-Paraffin: HSD17B1 Antibody [NBP1-84901] Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in Syncytiotrophoblasts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

per page
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