17-beta-HSD1 / HSD17B1 antibody

Principal name

17-beta-HSD1 / HSD17B1 antibody

Alternative names for 17-beta-HSD1 / HSD17B1 antibody

20 alpha-hydroxysteroid dehydrogenase, 20-alpha HSD, 17E2DH, EDH17B1, EDH17B2, EDHB17, E17KSR, Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, Placental 17-beta-hydroxysteroid dehydrogenase

SwissProt ID

P14061 (Human), P51656 (Mouse), P51657 (Rat)

Gene ID

3292 (HSD17B1), 25322 (Hsd17b1), 15485

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of 17-beta-HSD1 / HSD17B1 antibody

HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I),also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase,is an enzyme that is responsible for the interconversion of estrone (E1) and estradiol (E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42 (81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42 (43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.

General readings

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

17-beta-HSD1 / HSD17B1 antibody

  Rabbit Polyclonal Anti-HSD17B1 Antibody  
WB Suggested Anti-HSD17B1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
0.1 ml / €360.00
  OriGene Technologies, Inc.

17-beta-HSD1 / HSD17B1 antibody

  Rabbit Polyclonal Anti-HSD17B1 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human placenta tissue, Primary antibody: (HSD17B1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second Rabbit IgG Purified Hu E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

17-beta-HSD1 / HSD17B1 (C-term) antibody

Western blot analysis of HSD17B1 Antibody (C-term) Cat.-No AP52108PU-N in SK-BR-3 cell line lysates (35ug/lane). This demonstrates the HSD17B1 antibody detected the HSD17B1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

3 Item(s)

per page
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