17-beta-HSD2 / HSD17B2 antibody

Principal name

17-beta-HSD2 / HSD17B2 antibody

Alternative names for 17-beta-HSD2 / HSD17B2 antibody

Testosterone 17-beta-dehydrogenase, 20-alpha HSD, E2DH, EDH17B2, Estradiol 17-beta-dehydrogenase 2, Microsomal 17-beta-hydroxysteroid dehydrogenase

SwissProt ID

P37059 (Human), P51658 (Mouse), Q62730 (Rat)

Gene ID

3294 (HSD17B2), 15486 (Hsd17b2), 79243

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F)

Background of 17-beta-HSD2 / HSD17B2 antibody

HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2.And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

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CRISPR

Catalog No. Species Donor Vector  

HSD17B2 - human gene knockout kit via CRISPR

HSD17B2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HSD17B2 - human gene knockout kit via CRISPR

HSD17B2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD17B2 - human gene knockout kit via CRISPR

HSD17B2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HSD17B2 - human gene knockout kit via CRISPR

HSD17B2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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