4-1BBL / TNFSF9 antibody

Principal name

4-1BBL / TNFSF9 antibody

Alternative names for 4-1BBL / TNFSF9 antibody

4-1BB ligand, CD137L, Tumor necrosis factor ligand superfamily member 9

SwissProt ID

P41273 (Human), P41274 (Mouse)

Gene ID

21950 (Tnfsf9), 8744 (TNFSF9), 3604 (TNFRSF9), 5328744 (IPR000836)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Neutralisation (NEUT), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN)

Background of 4-1BBL / TNFSF9 antibody

4-1BB ligand (4-1BBL) is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF9. Mouse 4-1BBL cDNA encodes a 309 amino acid residues (aa) protein with an 82 aa Nterminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares only low aa sequence homology (14-16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. A soluble 4-1BBL is released from the cell surface following cellular activation via proteolytic cleavage by one or more sheddases. By analogy to other TNFSF ligands, both the soluble and transmembrane 4-1BBL are expected to exist as noncovalent homotrimers. 4-1BBL binds 4-1BB, a TNF receptor superfamily member, TNFRSF9, which is also known as CD137 and ILA (induced by lymphocyte activation). 41BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils. In response to 4-1BBL binding, 4-1BB transduces a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In dendritic cells, 4-1BB is a DC-activating molecule that enhances cytokine production and upregulates expression of B71 and B72 costimulatory molecules.

General readings

Lee SW., et al. (2008). Nat Immunol. 9(8):917-26.
Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26.

Items 1 to 20 of 35 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

4-1BBL / TNFSF9 antibody

Western blot analysis of extracts from HUVEC cells, using TNFSF9 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

4-1BBL / TNFSF9 antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human colon/rectum adenocarcinoma.  The recommended concentration is 0.25 mg/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Proteinase K antigen retrieval is recommended.  Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

4-1BBL / TNFSF9 antibody

Western blot (WB) analysis of 4-1BBL antibody Cat.-No. AP20383PU-N) at 1/500 dilution: Lane 1: Hela cell lysate. Lane 2: sp2/0 cell lysate.Lane 3: Rat liver tissue lysate. Lane 4: H9C2 cell lysate. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 (Extracell. Dom.) antibody

4-1BBL / TNFSF9 Rat IgG2 3H19 Purified Ms F, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG1 AT113-2 Aff - Purified Ms F, IP
0.25 mg / €400.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG1 AT113-2 Purified Ms F, IP
25 µg / €170.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG1 AT113-2 PE Ms F
100 Tests / €330.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG1 AT113-2 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Mouse IgG2a 1D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Mouse IgG1 3D6 Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

4-1BBL / TNFSF9 antibody

Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

4-1BBL / TNFSF9 antibody

Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

4-1BBL / TNFSF9 (C-term) antibody

Human HepG2; WB Suggested Anti-TNFSF9 Antibody. . Titration: 1.0 ug/ml. . Positive Control: HepG2 Whole Cell; TNFSF9 antibody - C-terminal region (ARP61434_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

4-1BBL / TNFSF9 antibody

Western blot analysis of CD137L expression in HeLa (A); SP2/0 (B); H9C2 (C); rat liver (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

4-1BBL / TNFSF9 antibody

Western blot analysis of CD137L expression in HeLa (A); SP2/0 (B); H9C2 (C); rat liver (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

4-1BBL / TNFSF9 antibody

Western blot analysis of CD137L expression in HeLa (A); SP2/0 (B); H9C2 (C); rat liver (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

4-1BBL / TNFSF9 antibody

HuT 78 (T lymphoma cell line) stained with purified 5F4, then detected with biotinylated antimouse IgG followed by Sav-PE Mouse IgG1 5F4 Aff - Purified Hu F
0.1 mg / €320.00
  Novus Biologicals Inc.

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG2 AP-MAB0875 Purified Ms C, F, IP, NEUT, P
0.5 mg / €380.00
  Novus Biologicals Inc.

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat IgG2 RM0067-3H19 Purified Ms F, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

Items 1 to 20 of 35 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn