4-Hydroxy-2-Nonenal / HNE antibody

Principal name

4-Hydroxy-2-Nonenal / HNE antibody

Alternative names for 4-Hydroxy-2-Nonenal / HNE antibody

4-HNE, 4-Hydroxynonenal, Hydroxynonenal

Available reactivities

All Species

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P)

Background of 4-Hydroxy-2-Nonenal / HNE antibody

4-hydroxynonenal is a 65 kDa, highly reactive aldehyde released upon oxidation of omega-6-insaturated fatty acids, often by free radicals. HNE acts to spread and increase the initial effects of free radical events. It binds nucleic acids, phospholipids and sulfhydryl, histidine and lysine groups. These conjugates cause the cytotoxic effects (including cell death) that occur during oxidative stress due to hydrogen peroxide, superoxide, UV, heat and oxidant chemicals. HNE plays a role in the pathogenesis of diseases, stimulating fibrogenesis and inflammation. It is thought to act as a sensor of external stimuli, inducing the stress response by modulating membrane receptors such as Epidermal growth factor receptor or Fas. It is thought that constitutive levels of HNE may be needed for normal cell functions as decreased HNE levels are associated with cell proliferation and increased HNE levels with elevated apoptosis.

General readings

Boon, P.J.M., et al., (1999), Tox. Appl. Pharmacol., 159, 214-223.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

4-Hydroxy-2-Nonenal / HNE antibody

Immunohistochemistry of 4-HNE staining in Paraffin section of colorectal adenocarcinoma. Antigen retrieval was performed in 10mM Citrate buffer pH6.0 at 120°C for 5 min. The section was incubated with 4-HNE antibody Cat.-No AM20225PU (10 µg/ml) followed by staining with  avidin-biotin-complex method. This antibody stains the cytoplasm of adenocarcinoma cells (arrow heads) stronger than non-tumorous epithelial cells (star). Original magnification: x240.
Kondo S et al.(1999). Free Radic Biol Med 27(3-4): 401-410. Mouse IgG1 HNEJ-2 Purified C, E, P, WB
20 µg / €360.00
  Acris Antibodies GmbH

4-Hydroxy-2-Nonenal / HNE antibody

4-Hydroxy-2-Nonenal / HNE Goat Serum E
1 ml / €1,010.00
  Acris Antibodies GmbH

4-Hydroxy-2-Nonenal / HNE antibody

4-Hydroxy-2-Nonenal / HNE Goat IgG Serum E, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

4-Hydroxy-2-Nonenal / HNE antibody

4-Hydroxy-2-Nonenal / HNE Goat IgG Purified E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

4-Hydroxy-2-Nonenal / HNE antibody

4-Hydroxy-2-Nonenal / HNE Rabbit IgG Purified E, WB
0.2 mg / €580.00
  Abnova Taiwan Corp.

4-Hydroxy-2-Nonenal / HNE antibody

4-Hydroxy-2-Nonenal / HNE Goat IgG E
1 ml / €390.00
  Abnova Taiwan Corp.

4-Hydroxy-2-Nonenal / HNE antibody

Western Blot: 4-Hyroxynonenal Antibody [NB100-63093] - Western blot of aged control and Alzheimer brain homogenates using 1:3,000 dilution of 4-HNE antiserum. Goat IgG All Species E, WB
50 µl / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

4-Hydroxy-2-Nonenal / HNE (BSA conjugated)

4-Hydroxy-2-Nonenal / HNE Purified Dialyzed to remove any free 4-HNE.
0.5 mg / €370.00
  Acris Antibodies GmbH

8 Item(s)

per page
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