4E-BP2 antibody

Principal name

4E-BP2 antibody

Alternative names for 4E-BP2 antibody

EIF4EBP2, eIF4E-binding protein 2, Eukaryotic translation initiation factor 4E-binding protein 2

SwissProt ID

P70445 (Mouse), Q13542 (Human)

Gene ID

1979 (EIF4EBP2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Chicken, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of 4E-BP2 antibody

PHAS-II, also known as eIF4E-binding protein II (eIF4E-BPII), is a member of a family of proteins which regulate initiation. PHAS-I and -II were found to have overlapping but different patterns of expression in tissues. PHAS-II shows the highest expression in liver and kidney where very little PHAS-I is found. The PHAS proteins regulate translation initiation by binding to the inhibitory protein eIF- 4E and blocking translation by preventing access of eIF-4G to the 5' cap of the mRNA. Both PHAS proteins are phosphorylated in response to insulin or growth factors such as EGF, PDGF and IGF-1. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes which allows eIF-4E to bind eIF-4G(p220), thereby increasing the amount of eIF-4F complex and the rate of translation initiation. Regulation of the two protein differ because PHAS-II, unlike PHAS-I is readily phosphorylated by PKA in vitro. However increasing cAMP in cells promotes dephosphorylation of both PHAS-I and PHAS-II. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II suggesting that these proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

4E-BP2 antibody

Western blot detection of 4E-BP2 in CHO-K1 cell lysate(A)and CHO-K1 transfected by EGFP-4E-BP2 (B)cell lysate using 4E-BP2 mouse mAb (1:1000 diluted). Mouse IgG1 7A6-B3-E5 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

4E-BP2 (99-120) antibody

Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

4E-BP2 antibody

4E-BP2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

4E-BP2 antibody

Western Blot analysis of EIF4EBP2 expression in transfected 293T cell line (H00001979-T01) by EIF4EBP2 MaxPab polyclonal antibody.

Lane 1: EIF4EBP2 transfected lysate(13.31 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

4E-BP2 antibody

4E-BP2 Mouse IgG2a 2G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

4E-BP2

4E-BP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

4E-BP2

4E-BP2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

4E-BP2 (1-120, His-tag)

Recombinant human EIF4EBP2, 1-120 aa, His-tagged Human Purified > 85 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

4E-BP2 (1-120, His-tag)

Recombinant human EIF4EBP2, 1-120 aa, His-tagged Human Purified > 85 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

4E-BP2

4E-BP2 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

4E-BP2

4E-BP2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

4E-BP2

4E-BP2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

4E-BP2

4E-BP2 Human Purified
0.1 mg / €380.00
  Novus Biologicals Inc.

4E-BP2

4E-BP2 Human Purified
0.5 mg / €870.00
  Novus Biologicals Inc.

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