8-Hydroxy-Guanosine / 8-OHG antibody

Principal name

8-Hydroxy-Guanosine / 8-OHG antibody

Alternative names for 8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-2'-deoxyguanosine, 8-Hydroxyguanine, 8-Hydroxyguanosine, 8-OFdG, 8-OHG, 8OG, 8OHG, 8OHdG

Available reactivities

All Species, Hu (Human), Bov (Bovine), Can (Canine), Fe (Feline), Ms (Mouse), Por (Porcine), Prim (Primate), Rt (Rat), Rb (Rabbit)

Available hosts

Mouse, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of 8-Hydroxy-Guanosine / 8-OHG antibody

DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatch of the bases. During the oxidation of bases, highly reactive chemical entities collectively known as RONS, occurs. RONS stands for reactive oxygen and nitrogen species and includes nitric oxide, superoxide, hydroxyl radical, hydrogen peroxide and peroxynitrite. Numerous studies have shown that RONS causes a variety of issues including DNA damage (1). 8-hydroxyguanine, 8-hydroxy-2’-deoxyguanonsine and 8-hydroxyguanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2’-guanosine is produced by reactive oxygen and nitrogen species including hydroxyl radical and peroxynitrite. Specifically its high biological relevance is due to its ability to induce G to T transversions, which is one of the most frequent somatic mutations (2). 8-hydroxy-guanine has been the most frequently studied type of DNA base damage, with studies in diabetes, and cancer. Base modifications of this type arise from radical-induced hydroxylation and cleavage reactions of the purine ring (3, 4). And finally, 8-hydroxy-guanosine, like 8-hydroxy-2’-guanosine, induces a mutagenic transversion of G to T in DNA. Its role has specifically been tested in the development of diabetes, hypertension and strokes (5, 6, and 7).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

8-Hydroxy-Guanosine / 8-OHG antibody

AM03160PU used against oxidized 8-OH-dG in ischemic Rat brain tissue (Left Panel). 
Center Panel: DAPI staining. 
Right Panel: merged. 
Courtesy of Dr. Yang, University of New Mexico, USA. Mouse IgG2b 15A3 Purified C, E, P
0.1 mg / €360.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

AM03160PU used against oxidized 8-OH-dG in ischemic Rat brain tissue (Left Panel). 
Center Panel: DAPI staining. 
Right Panel: merged. 
Courtesy of Dr. Yang, University of New Mexico, USA. Mouse IgG2b 15A3 Purified C, E, ICC/IF, P
25 µg / €210.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

Immunohistochemistry: AM20226PU 8-OHdG antibody staining of Paraffin Section of  UV-irradiated Mouse Skin using an antigen retrieval  in 0.1% Trypsin. The section was incubated with AM20226PU (5 µg/ml), followed by staining with Avidin-Biotin-Complex method. This antibody stains epidremal cells and some infiltrating neutrophils and macrophages.
(See Ref.3 for more details). Mouse IgG1 N45.1 Purified Hu, Ms, Rb, Rt E, ICC/IF, P
20 µg / €590.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG Mouse IgG2b 15A3 Purified C, E, ICC/IF
0.1 mg / €580.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG Goat Serum C, E, P
0.2 ml / €350.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG Goat Serum E, P
0.1 ml / €400.00
  Acris Antibodies GmbH

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG
0.1 mg / €560.00
  Abnova Taiwan Corp.

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG Goat IgG E, P
0.2 ml / €400.00
  Abnova Taiwan Corp.

8-Hydroxy-Guanosine / 8-OHG antibody

Alzheimer's Disease brain showing immunohistochemical staining of oxidized RNA in neurons. Tissue sections were formalin-fixed, paraffin embedded and pretreated with 10 ug/ml proteinase K for 40 minutes at 37OC followed by staining with a 1:200 dilution of 8-hydroxyguanosine antibody. Goat IgG Serum Bov, Can, Fe, Hu, Ms, Por, Prim, Rt P
0.1 ml / €380.00
  Neuromics Antibodies

8-Hydroxy-Guanosine / 8-OHG antibody

8-Hydroxy-Guanosine / 8-OHG Mouse IgG2a 3H30 Purified All Species E
25 µg / €400.00
  Novus Biologicals Inc.

8-Hydroxy-Guanosine / 8-OHG antibody

Immunohistochemistry: 8-Hydroxyguanosine Antibody [NB600-1508] - Goat anti-8-OHdG Alzheimer disease brain showing immunohistochemcal staining of oxidized DNA in neurons. Tissue sections were formalin-fixed, paraffin-embedded with either (A) no pretreatment, or (B) pretreated with 10 mg/mL proteinase K for 40 minutes at 37°C. and stained with a 1:200 dilution of AB5830. Goat IgG Serum Hu E, P
50 µl / €310.00
  Novus Biologicals Inc.

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