AADC / DDC antibody

Principal name

AADC / DDC antibody

Alternative names for AADC / DDC antibody

DOPA decarboxylase, Aromatic-L-amino-acid decarboxylase

SwissProt ID

O88533 (Mouse), P14173 (Rat), P20711 (Human), P27718 (Bovin), P80041 (Pig)

Gene ID

1644 (DDC), 280762, 24311 (Ddc), 13195

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Ze (Zebrafish), African clawed frog, GP (Guinea Pig), Rb (Rabbit), Sh (Sheep), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), EPair for Elisa (EPair)

Background of AADC / DDC antibody

DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.

General readings

Voeller KK. Attention-deficit hyperactivity disorder (ADHD). J Child Neurol. 2004 Oct;19(10):798-814.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AADC / DDC antibody

  Rabbit Anti-DOPA Decarboxylase, Bovine Antibody  
Western blot of rat adrenal medulla.  As shown in the autoradiograph, the antibody is specific for the ~55k DDC protein. Rabbit IgG Aff - Purified Bov, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AADC / DDC (N-term) antibody

  Rabbit Anti-DOPA Decarboxylase, Human Antibody  
Western blot of 5 μg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein. Rabbit IgG Aff - Purified Bov, Can, GP, Hu, Rb, Rt, Sh WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AADC / DDC antibody

  Goat Polyclonal Antibody against DOPA decarboxylase  
TA302469 (0.03µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AADC / DDC antibody

  Rabbit Polyclonal DDC Antibody  
Western blot analysis of DDC in human lung tissue lysate with DDC antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AADC / DDC antibody

  Rabbit Polyclonal Anti-DDC Antibody  
WB Suggested Anti-DDC Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysateDDC is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AADC / DDC antibody

  Rabbit Polyclonal Anti-DDC Antibody  
WB Suggested Anti-DDC Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Spleen Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AADC / DDC antibody

AADC / DDC Rabbit IgG Purified Bov, Rt WB
0.1 ml / €500.00
  Acris Antibodies GmbH

AADC / DDC antibody

AADC / DDC Mouse IgG2b 413911 Purified Hu, Rt C, E, WB
0.1 mg / €340.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

DDC - human gene knockout kit via CRISPR

DDC - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DDC - human gene knockout kit via CRISPR

DDC - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DDC - human gene knockout kit via CRISPR

DDC - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DDC - human gene knockout kit via CRISPR

DDC - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddc - mouse gene knockout kit via CRISPR

Ddc - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ddc - mouse gene knockout kit via CRISPR

Ddc - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddc - mouse gene knockout kit via CRISPR

Ddc - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddc - mouse gene knockout kit via CRISPR

Ddc - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AADC / DDC (transcript variant 2)

  Recombinant protein of human dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 2  
AADC / DDC Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AADC / DDC (transcript variant 1)

  Recombinant protein of human dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 1  
AADC / DDC Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AADC / DDC (1-480, His-tag)

Dopa decarboxylase, 1-480 aa human, His-tagged, recombinant: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

AADC / DDC (1-480, His-tag)

Dopa decarboxylase, 1-480 aa human, His-tagged, recombinant: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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