ABC2 / SMG8 antibody

Principal name

ABC2 / SMG8 antibody

Alternative names for ABC2 / SMG8 antibody

UPF0487 protein C17orf71, Amplified in breast cancer gene 2 protein

SwissProt ID

Q8ND04 (Human), Q8VE18 (Mouse)

Gene ID

55181 (SMG8)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB)

Background of ABC2 / SMG8 antibody

ABC2 or SMG8 is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It ss recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). SMG8 acts as a regulator of kinase activity.

General readings

"SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." Yamashita A., Izumi N., Kashima I., Ohnishi T., Saari B., Katsuhata Y., Muramatsu R., Morita T., Iwamatsu A., Hachiya T., Kurata R., Hirano H., Anderson P., Ohno S. Genes Dev. 23:1091-1105(2009)

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  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABC2 / SMG8 antibody

Host:Rabbit; Target Name:SMG8; Sample Tissue:Human Adult Placenta; Antibody Dilution: 1.0 ug/ml Rabbit Aff - Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

ABC2 / SMG8 antibody

Hum. Fetal Heart; Host:Rabbit. Target Name:SMG8. Sample Tissue:Human Fetal Heart. Antibody Dilution: 1.0ug/ml.; C17orf71 antibody - middle region (ARP57129_P050) in Hum. Fetal Heart cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

ABC2 / SMG8 antibody

ABC2 / SMG8 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ABC2 / SMG8 antibody

Immunohistochemistry-Paraffin: ABC2 Antibody [NB100-74598] - FFPE section of human thyroid carcinoma. Antibody: Affinity purified rabbit anti-ABC2 used at  a dilution of 1:250. Detection: DAB staining using  Immunohistochemistry Accessory Kit Rabbit IgG Aff - Purified Hu IP, P
0.1 mg / €440.00
  Novus Biologicals Inc.

ABC2 / SMG8 antibody

Western Blot: ABC2 Antibody [NBP1-56876] - This Anti-C17orf71 antibody was used in Western Blot of 721_B       tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

ABC2 / SMG8 antibody

Immunohistochemistry-Paraffin: ABC2 Antibody [NBP1-87918] Immunohistochemical staining of human small intestine shows strong positivity in goblet cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ABC2 / SMG8

ABC2 / SMG8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SMG8 overexpression lysate

SMG8 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

8 Item(s)

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