Alternative names for ABCA3 antibody
ABC3, ABC-C transporter, ATP-binding cassette sub-family A member 3
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of ABCA3 antibody
ABCA3 plays an important role in the formation of pulmory surfactant, probably by transporting lipids such as cholesterol.Defects in ABCA3 are the cause of pulmory surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmory alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.