ABCB3 / APT2 / TAP2 antibody

Principal name

ABCB3 / APT2 / TAP2 antibody

Alternative names for ABCB3 / APT2 / TAP2 antibody

PSF2, RING11, Y1, Antigen peptide transporter 2, ATP-binding cassette sub-family B member 3, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter involved in antigen processing 2

SwissProt ID

P36371 (Mouse), P36372 (Rat), Q03519 (Human)

Gene ID

6891 (TAP2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ABCB3 / APT2 / TAP2 antibody

TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. TAP is also inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP is down-regulated by human Epstein-barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren's syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.

General readings

1. Nijenhuis, M., et al. J. Immunol. 156, 2186-2195 (1996)
2. Nijenhuis, M., et al. J. Immunol. 157, 5467-5477 (1996)
Clone TAP2.17 is used in these references.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCB3 / APT2 / TAP2 (689-703) antibody

Anti-TAP2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit IgG Aff - Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

ABCB3 / APT2 / TAP2 antibody

Western blot analysis of extracts of placenta cell lines, using TAP2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCB3 / APT2 / TAP2 (434-703) antibody

Immunohistochemistry: AM20195AF-N TAP2 antibody staining of Human Paraffin Embedded Breast Cancer Section. Mouse IgG1 TAP1.28 Azide Free Hu F, IP, P, WB
0.1 mg / €310.00
  Acris Antibodies GmbH

ABCB3 / APT2 / TAP2 antibody

ABCB3 / APT2 / TAP2 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

ABCB3 / APT2 / TAP2 antibody

ABCB3 / APT2 / TAP2 Mouse IgG1 TAP2.17 Purified Hu, Ms, Rt C, IP, WB
50 µg / €320.00
  Novus Biologicals Inc.

ABCB3 / APT2 / TAP2 antibody

Immunohistochemistry-Paraffin: TAP2 Antibody [NBP1-89312] - Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in cells in seminiferus ducts. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ABCB3 / APT2 / TAP2

ABCB3 / APT2 / TAP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ABCB3 / APT2 / TAP2

ABCB3 / APT2 / TAP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ABCB3 / APT2 / TAP2

ABCB3 / APT2 / TAP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ABCB3 / APT2 / TAP2

ABCB3 / APT2 / TAP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

10 Item(s)

per page
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