ABCC1 / MRP1 antibody

Principal name

ABCC1 / MRP1 antibody

Alternative names for ABCC1 / MRP1 antibody

Multidrug resistance-associated protein 1, LTC4 transporter, ATP-binding cassette sub-family C member 1

SwissProt ID

O35379 (Mouse), P33527 (Human), Q8CG09 (Rat)

Gene ID

4363 (ABCC1), 24565 (Abcc1), 17250

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C)

Background of ABCC1 / MRP1 antibody

ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

General readings

1. Pei QL, Koyabashi Y, Tanaka Y, Taguchi Y, Higuchi K, Kaito M, Ma N, Semba R, Kamisako T, Adachi Y. Increased expression of multidrug resistance-associated protein 1
(mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res. 2002 January; 22(1): 58-64.
2. Thews O, Gassner B, Kelleher DK, Gekle M. Activity of drug efflux transporters in tumor cells under hypoxic conditions. Adv Exp Med Biol. 2008; 614: 157-164.
3. Yang JJ, Ann DK, Kannan R, Lee VH. Multidrug resistance protein 1 (MRP1) in rabbit conjuctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection.
Pharm Res. 2007 August; 24(8): 1490-1500.
4. Dorajoo R, Pereira BP, Yu Z, Gopalakrishnakone P, Leong CC, Wee A, Lee E. Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy. Life Sci.
2008 April; 82(15-16): 823-830.
5. Eilers M, Roy U, Mondal D. MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir and zidovudine, from human endothelial cells. Exp Biol
Med (Maywood). 2008 September; 233(9): 1149-1160.
6. Mitra P, Oskeritizian CA, Payne SG, Beaven MA, Milstien S, Spiegel S. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006
October; 103(44): 16394-16399.

  1. Quick-Filters:
  2. Highly Validated (1)

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC1 / MRP1 antibody

  Mouse Monoclonal MRP1 Antibody (IU2H10)  
Western Blot: MRP1 Antibody (IU2H10) - Western Blot detection of MRP1 1: Vector-transfected HEK293 cells  2: MRP1-transfected cells, prep1 3: MRP1-transfected cells, prep2 (the lower band is a degradation product. Mouse IgG1 IU2H10 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

  Goat Anti-ABCC1 Antibody  
TA305869 (0.05ug/ml) staining of A549 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

  Mouse Monoclonal MRP1 Antibody (IU5C1)  
Western Blot: MRP1 Antibody (IU5C1) -Detection of MRP1 in 10 ug of 293 transfected (lane 2) and empty vector (lane 1) lysate. Mouse IgG1 IU5C1 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

  Anti-ABCC1 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human colon cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ABCC1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

  Anti-ABCC1 Rabbit Polyclonal Antibody  
Predicted band size: 173 kDa . Positive control: Human fetal lung tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

  Rabbit Polyclonal Anti-ABCC1 Antibody  
WB Suggested Anti-ABCC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Rat IgG2a MRPr1 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG1 MRPm6 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 (C-term) antibody

Western blot analysis of ABCC1 antibody (C-term) in Ramos cell line lysates (35 µg/lane). ABCC1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ABCC1 - human gene knockout kit via CRISPR

ABCC1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ABCC1 - human gene knockout kit via CRISPR

ABCC1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ABCC1 - human gene knockout kit via CRISPR

ABCC1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ABCC1 - human gene knockout kit via CRISPR

ABCC1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Abcc1 - mouse gene knockout kit via CRISPR

Abcc1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Abcc1 - mouse gene knockout kit via CRISPR

Abcc1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Abcc1 - mouse gene knockout kit via CRISPR

Abcc1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Abcc1 - mouse gene knockout kit via CRISPR

Abcc1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ABCC1 overexpression lysate

ABCC1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ABCC1 (mGFP-tagged) - Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ABCC1 (mGFP-tagged) - Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, ABCC1 (Myc-DDK tagged) - Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ABCC1 (Myc-DDK tagged) - Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

20 Item(s)

per page
  • LinkedIn