ABCC1 / MRP1 antibody

Principal name

ABCC1 / MRP1 antibody

Alternative names for ABCC1 / MRP1 antibody

Multidrug resistance-associated protein 1, LTC4 transporter, ATP-binding cassette sub-family C member 1

SwissProt ID

O35379 (Mouse), P33527 (Human), Q8CG09 (Rat)

Gene ID

24565 (Abcc1), 4363 (ABCC1)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Mky (Monkey), Fe (Feline), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP), Flow Cytometry (F)

Background of ABCC1 / MRP1 antibody

ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

General readings

1. Pei QL, Koyabashi Y, Tanaka Y, Taguchi Y, Higuchi K, Kaito M, Ma N, Semba R, Kamisako T, Adachi Y. Increased expression of multidrug resistance-associated protein 1
(mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res. 2002 January; 22(1): 58-64.
2. Thews O, Gassner B, Kelleher DK, Gekle M. Activity of drug efflux transporters in tumor cells under hypoxic conditions. Adv Exp Med Biol. 2008; 614: 157-164.
3. Yang JJ, Ann DK, Kannan R, Lee VH. Multidrug resistance protein 1 (MRP1) in rabbit conjuctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection.
Pharm Res. 2007 August; 24(8): 1490-1500.
4. Dorajoo R, Pereira BP, Yu Z, Gopalakrishnakone P, Leong CC, Wee A, Lee E. Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy. Life Sci.
2008 April; 82(15-16): 823-830.
5. Eilers M, Roy U, Mondal D. MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir and zidovudine, from human endothelial cells. Exp Biol
Med (Maywood). 2008 September; 233(9): 1149-1160.
6. Mitra P, Oskeritizian CA, Payne SG, Beaven MA, Milstien S, Spiegel S. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006
October; 103(44): 16394-16399.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC1 / MRP1 antibody

Western Blot: MRP1 Antibody (IU2H10) - Western Blot detection of MRP1 1: Vector-transfected HEK293 cells  2: MRP1-transfected cells, prep1 3: MRP1-transfected cells, prep2 (the lower band is a degradation product. Mouse IgG1 IU2H10 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

TA305869 (0.05ug/ml) staining of A549 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

Western Blot: MRP1 Antibody (IU5C1) -Detection of MRP1 in 10 ug of 293 transfected (lane 2) and empty vector (lane 1) lysate. Mouse IgG1 IU5C1 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

Predicted cell location: Nucleus. Positive control: Human colon cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ABCC1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

Predicted band size: 173 kDa . Positive control: Human fetal lung tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

WB Suggested Anti-ABCC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG2a MRPm5 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Rat IgG2a MRPr1 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG1 MRPm6 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 Control Peptide

ABCC1 / MRP1
0.25 mg / €250.00
  Acris Antibodies GmbH

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

ABCC1 / MRP1 (C-term) antibody

Western blot analysis of ABCC1 antibody (C-term) in Ramos cell line lysates (35 µg/lane). ABCC1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG1 1G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

Western blot analysis of ABCC1 in 10 µg of 293 transfected lysate using ABCC1 monoclonal antibody, clone IU5C1 ( Cat # MAB2374 ). Lane 1 : empty vector. Lane 2 : ABCC1 transfected 293 lysate. Mouse IgG1 IU5C1 Hu, Ms ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

Western blot analysis of MRP1 using ABCC1 monoclonal antibody, clone IU2H10 ( Cat # MAB2388 ) on vector-transfected HEK293 cells ( lane1 ), MRP1-transfected cells, prep1 ( lane 2 ) and MRP1-transfected cells, prep2 ( Lane 3 ). The lower band is a degradation product. Mouse IgG1 IU2H10 Hu, Ms ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG2b QCRL-2 Hu, Mky Dot, F, ICC/IF, IP
1 ml / €730.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG2a 33A6 Hu P
1 ml / €1,080.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG2a QCRL-3 Hu F, ICC/IF, IP
1 ml / €730.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

ABCC1 / MRP1 Mouse IgG1 QCRL-4 Hu, Mky, Ms, Rt Dot, F, ICC/IF, IP
1 ml / €730.00
  Abnova Taiwan Corp.

ABCC1 / MRP1 antibody

ABCC1 polyclonal antibody ( Cat # PAB11480 ) ( 0.05 µg/ml ) staining of A-549 lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

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