ABCC2 / CMOAT / MRP2 antibody

Principal name

ABCC2 / CMOAT / MRP2 antibody

Alternative names for ABCC2 / CMOAT / MRP2 antibody

CMOAT1, CMRP, Multidrug resistance-associated protein 2, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, Canalicular multispecific organic anion transporter 1

SwissProt ID

Q63120 (Rat), Q8VI47 (Mouse), Q92887 (Human)

Gene ID

1244 (ABCC2), 12780 (Abcc2), 25303

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Rb (Rabbit), Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP)

Background of ABCC2 / CMOAT / MRP2 antibody

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the asolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.

cMOAT/MRP2 is a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC2 / CMOAT / MRP2 antibody

Western blot analysis of extracts from RAW264.7 cells, using ABCC2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC2 / CMOAT / MRP2 antibody

WB Suggested Anti-Abcc2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Mouse Spleen Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2b M2III-5 Supernatant Hu, Ms, Rt C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2a M2II-12 Supernatant Hu C, ICC/IF, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2a M2III-6 Supernatant Hu C, ICC/IF, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG1 M2I-4 Supernatant Hu C, ICC/IF, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

Detection limit for recombinant GST tagged ABCC2 is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 1C5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG1 1C5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG1 2H6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2a M2II-12 Hu C, F, ICC/IF, WB
0.5 ml / €640.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2b M2III-5 Hu, Ms, Rt C, F, ICC/IF, P, WB
1 ml / €820.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Rabbit Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

ABCC2 / CMOAT / MRP2 antibody

Western blot analysis of MRP2 expression in HeLa (A); mouse brain (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

ABCC2 / CMOAT / MRP2 antibody

Western blot analysis of MRP2 expression in HeLa (A); mouse brain (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

ABCC2 / CMOAT / MRP2 antibody

Western blot analysis of MRP2 expression in HeLa (A); mouse brain (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG1 M2I-4 Hu ICC/IF, IP, WB
0.25 ml / €380.00
  Novus Biologicals Inc.

ABCC2 / CMOAT / MRP2 antibody

ABCC2 / CMOAT / MRP2 Mouse IgG2a M2III-6 Hu C, F, ICC/IF, P, WB
0.2 ml / €300.00
  Novus Biologicals Inc.

ABCC2 / CMOAT / MRP2 antibody

Western Blot: MRP2 Antibody [NBP1-69023] Rabbit Aff - Purified Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

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