ABCC4 / MRP4 antibody

Principal name

ABCC4 / MRP4 antibody

Alternative names for ABCC4 / MRP4 antibody

Multidrug resistance-associated protein 4, MOAT-B, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B

SwissProt ID

O15439 (Human)

Gene ID

10257 (ABCC4), 819392 (MRP4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit)

Available hosts

Mouse, Rat, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP)

Background of ABCC4 / MRP4 antibody

ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White . ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also med MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines . ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds . The diversity of substrates determines the biological functions of ABCC4. It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells. ABCC4 also ebles COX deficient pancreatic cancer cells to obtain exogenous prostagladins . Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy . ABCC4 localizes to both plasma membrane and intracellular membranous structures . Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis .

General readings

Schuetz JD et al. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5:1048-51 (1999). PubMed: 10470083

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC4 / MRP4 (C-term) antibody

TA302970 staining (0.5µg/ml) of rat renal cortex membranes (20µg total protein per lane). Detected by western blot using chemiluminescence.  Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald. Goat Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCC4 / MRP4 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1B2 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

ABCC4 / MRP4 (70-82) antibody

AP23671PU-N ABCC4 antibody staining of Human Prostate lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

ABCC4 / MRP4 antibody

Western blot analysis of extracts of kindney cell lines, using ABCC4 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rat IgG2a M4I-80 Supernatant Hu C, ICC/IF, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rat IgG2a M4I-10 Supernatant Hu C, ICC/IF, WB
1 ml / €420.00
  Acris Antibodies GmbH

ABCC4 / MRP4 (1249-1268) antibody

state: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu C, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

ABCC4 / MRP4 (C-term) antibody

Western blot analysis of anti-ABCC4 Antibody (C-term) in CEM cell line lysates (35ug/lane). ABCC4 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ABCC4 / MRP4 antibody

Immunoperoxidase of monoclonal antibody to ABCC4 on formalin-fixed paraffin-embedded human prostate. [antibody concentration 3 ug/ml] Mouse IgG1 1B2 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rat IgG2a M4I-10 Hu, Ms C, F, ICC/IF, WB
1 ml / €820.00
  Abnova Taiwan Corp.

ABCC4 / MRP4 antibody

ABCC4 polyclonal antibody ( Cat # PAB6698 ) ( 2.5 µg/ml ) staining of paraffin embedded human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu, Rt E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rabbit Hu, Rb, Rt C, WB
0.2 ml / €560.00
  Abnova Taiwan Corp.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

ABCC4 / MRP4 antibody

Immunohistochemistry: MRP4 Antibody [NB100-1471] -  MRP4 Antibody [NB100-1471] - NB100-1478 (2.5ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ABCC4 / MRP4 antibody

Western Blot: MRP4 Antibody [NBP1-05996] - Detection of Human MRP4 by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-MRP4 antibody NBP1-05996 used for IP at 3 mcg/mg  lysate. MRP4 was also immunoprecipitated by another rabbit anti-MRP4  antibody, which recognizes a downstream epitope. Rabbit IgG Aff - Purified Hu IP
0.1 ml / €440.00
  Novus Biologicals Inc.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rat IgG2a M4I-80 Hu, Ms C, F, ICC/IF, P, WB
0.2 ml / €290.00
  Novus Biologicals Inc.

ABCC4 / MRP4 antibody

ABCC4 / MRP4 Rat IgG2a M4I-10 Hu, Ms C, ICC/IF, P, WB
0.2 ml / €290.00
  Novus Biologicals Inc.

ABCC4 / MRP4 antibody

Immunohistochemistry-Paraffin: MRP4 Antibody [NBP1-84782] Immunohistochemical staining of human prostate shows cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ABCC4 / MRP4

ABCC4 / MRP4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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