ABCC7 / CFTR antibody

Principal name

ABCC7 / CFTR antibody

Alternative names for ABCC7 / CFTR antibody

Cystic fibrosis transmembrane conductance regulator, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7

SwissProt ID

P13569 (Human), P26361 (Mouse), P34158 (Rat), Q00555 (Sheep)

Gene ID

1080 (CFTR)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of ABCC7 / CFTR antibody

The cystic fibrosis transmembrane conductance regulator (CFTR) is the most domint Cl channel in several epithelial tissues, especially in lung and colon. Remarkably, CFTR is a member of the ATP-binding cassette (ABC) transporter superfamily that uses ATP hydrolyzation as the driving force for the translocation of a wide variety of substrates including sugars, amino acids, proteins and hydrophobic compounds, across cellular membranes. The CFTR is unique among ABC transporters in that it is a cAMP-regulated Cl channel. It shares the superfamily topology of 12 transmembrane domains with two nucleotide-binding domains (NBDs) and a regulatory (R) domain in the large third intracytoplasmic loop that is phosphorylated in multiple sites by PKA. Mutations in the CFTR gene cause channel dysfunction in several ways, ranging from complete loss of surface expression to diminished Cl secretion. Defects in the CFTR gene cause cystic fibrosis (CF), the most common genetic disease among Caucasians, as well as a form of male sterility. Regulation of the CFTR channel is accomplished through the activation of surface receptors that couple to adenyl cyclase, raise cAMP cellular levels and thus activate PKA. This has been demonstrated for the adenosine and Ã?2 adrenergic receptor and the vasopressin hormone among others. Besides enhanced Cl conductance, activation of CFTR also leads to the regulation of other ion channels. The best-studied case is its interaction with the epithelial + channels (EC), although it can probably regulate other ion channels as well (Kir1.1 for example). The mechanism by which CFTR regulates other ion channels is not clear, but it may involve protein-protein interactions via molecules that interact with its C-termil PDZ binding motif, such as the NHERF adaptor protein.

General readings

This product has been used in:Walker J et al. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci 108 (Pt 6):2433-44 (1995). PubMed PMID: 7545688
General / background references:Pier GB et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature 393:79-82 (1998). PubMed PMID: 9590693

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC7 / CFTR antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CFTR antibody at dilution 1/8, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC7 / CFTR antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human liver cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CFTR antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABCC7 / CFTR antibody

Western blot analysis of rat lung membranes: 1. Anti-CFTR antibody, (1:200). 2. Anti-CFTR antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ABCC7 / CFTR antibody

Western blot analysis of CFTR in human small intestine tissue lysate with CFTR antibody at  1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABCC7 / CFTR antibody

Immunohistochemistry (IHC) analysis of CFTR antibody (Cat.-No.: AP06511PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

ABCC7 / CFTR antibody

BHK cells expressing wild-type (wt) CFTR or mutated (rΔF508) CFTR, were fixed, permeabilized, and CFTR protein was detected with the specific anti-CFTR antibody . Rabbit Purified Hu E, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

ABCC7 / CFTR antibody

BHK cells expressing wild-type (wt) CFTR or mutated (rΔF508), were fixed, permeabilized, and CFTR protein was detected with the specific CFTR antibody Cat.-No AP10443SU-N Rabbit Serum Hu E, ICC/IF, IP, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

ABCC7 / CFTR (2-14) antibody

AP23980PU-N ABCC7/CFTR antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate. Goat IgG Aff - Purified Armadillo, Bov, Bt, Can, Eq, Fe, Ft, GP, Hu, Mky, Por, Prim, Sh P
50 µg / €470.00
  Acris Antibodies GmbH

ABCC7 / CFTR antibody

DM378 CFTR antibody staining of Formalin Fixed, Paraffin Embedded Human Pancreas. Mouse IgG1 M3A7 Purified Hu P
1 ml / €720.00
  Acris Antibodies GmbH

ABCC7 / CFTR antibody

DM378 CFTR antibody staining of Formalin Fixed, Paraffin Embedded Human Pancreas. Mouse IgG1 M3A7 Purified Hu P
0.5 ml / €460.00
  Acris Antibodies GmbH

ABCC7 / CFTR antibody

ABCC7 / CFTR Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ABCC7 / CFTR antibody

ABCC7 / CFTR Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ABCC7 / CFTR antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

ABCC7 / CFTR antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

ABCC7 / CFTR antibody

Immunohistochemistry: CFTR Antibody [NB100-92156] - Immunohistochemistry (IHC) analysis of CFTR  (E733) antibody in paraffin-embedded human colon  carcinoma tissue Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

ABCC7 / CFTR antibody

ABCC7 / CFTR Mouse IgM CF3 Ascites Hu, Ms, Rt F, ICC/IF, IP, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

ABCC7 / CFTR antibody

Figure 1 shows immunolocalization of CFTR in HEK293 cells stably transfected with the CFTR gene. Rabbit Aff - Purified Hu ICC/IF, IP, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ABCC7 / CFTR antibody

Immunohistochemistry-Paraffin: CFTR Antibody (M3A7) [NB600-577] - Formalin fixed paraffin embedded human pancreas stained with CFTR antibody. Mouse IgG1 M3A7 Ig Fraction Hu P
0.5 ml / €440.00
  Novus Biologicals Inc.

ABCC7 / CFTR antibody

ABCC7 / CFTR Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

ABCC7 / CFTR antibody

ABCC7 / CFTR Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

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