ABCC8 antibody

Principal name

ABCC8 antibody

Alternative names for ABCC8 antibody

HRINS, SUR, SUR1, Sulfonylurea receptor 1, ATP-binding cassette transporter sub-family C member 8

SwissProt ID

Q09428 (Human), Q09429 (Rat)

Gene ID

6833 (ABCC8), 25559 (Abcc8)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Hst (Hamster)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ABCC8 antibody

The relation ship between glucose metabolism and insulin secretion from the pancreatic beta cells is linked with ATP-sensitive potassium channels (KATP). IN response to glucose metabolism, the ATP-sensitive potassium channels are inactivated due to an increase in ATP/ADP ratio, resulting in membrane depolarization and calcium influx through voltage dependent L-type Ca+2 channels. The KATPs are composed 4 units of inwardly rectifying K channel subunit (Kir6.2) and 4 copies of regulatory subunit SUR1 in an octameric complex. SUR 1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located (1). It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon-like peptide receptor1 (2). Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

SUR1 is a 1581 amino acid protein with an ATP binding domain with two nucleotide-binding folds (NBFs) and binding sites for sulfonylureas, like glibenclamide, and for channel openers. SUR contains three hydrophobic domains, TM(0), TM(1), and TM(2), with nucleotide binding folds following TM(1) and TM(2). The protein is glycosylated at position 10 on Asn. The SUR1 gene is expressed in at least 4 multiple splice variants ere are multiple splice variants, these splice variants originate from the splicing of the coding region of NFB and lack of axon 17 (SUR1Delta17), axon 19 (SUR1Delta 19) and both (SUR1Delta 17/19) and the fourth is a COOH terminal fragment formed by Exxon 31-39 containing the last 2 TMD and the COOH terminal (SUR1C). The various splice variants of SUR1 are expressed in various tissues with strong expression of SUR1C in cardiomyocytes (3). Only SUR1 and SUR1Delta 17 exhibit high affinity binding sites for sulfonylurea and other pharmacological agents. Several point mutations in the NFB region of SUR1 are also described in NIDDM. A total of five amino acid substitutions and 17 silent mutations were noted by examining all 39 axons of this gene in NIDDM patients form Japan. Two rare novel mutations, D811N in axon 20 and R835C in axon 21, were identified in the first nucleotide-binding fold (NBF), a functionally important region of SUR1, in one patient each, both heterozygotes.

General readings

de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM.
Increased ATPase activity produced by mutations at arginine-1380 in nucleotidebinding domain 2 of ABCC8 causes neonatal diabetes.
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92.
PMID: 18025464

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABCC8 antibody

Immunohistochemistry: SUR1 Antibody - Strong membranous staining pattern observed in colo-rectal cancers by immunohistochemistry.  Image is provided courtesy of the Swedish Human Proteome Resource (HPR) Center. Rabbit IgG Purified Hu E, P
0.1 mg / €360.00
  OriGene Technologies, Inc.

ABCC8 antibody

Immunohistochemistry: SUR1 Antibody [19600002] - IHC using anti ABCC8 SEQer antibody Rabbit Hu E, P
50 µg / €500.00
  Novus Biologicals Inc.

ABCC8 (C-term) antibody

Antibody (0.5µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

ABCC8 (1548-1582, Cytopl. Dom.) antibody

ABCC8 Mouse IgG1 S289-16 Purified Hst, Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

ABCC8 Control Peptide

ABCC8
0.1 mg / €250.00
  Acris Antibodies GmbH

ABCC8 antibody

ABCC8 Rabbit IgG Aff - Purified Hu Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

ABCC8 C-term antibody

GTX88616 (0.5µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Can, Hu, Ms, Rt E, WB

Regular Price: 0.1 mg / €360.00

Special Price: 0.1 mg / €306.00

  GeneTex Inc.

ABCC8 antibody

ABCC8 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ABCC8 antibody

ABCC8 Mouse Hu WB
0.5 mg / €1,420.00
  Abnova Taiwan Corp.

ABCC8 antibody

Detection limit for recombinant GST tagged ABCC8 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 3G5 Purified Hu E, WB
0.1 mg / €360.00
  Abnova Taiwan Corp.

ABCC8 antibody

ABCC8 Mouse IgG2a 3G5 Ascites Hu E, WB
0.2 ml / €360.00
  Abnova Taiwan Corp.

ABCC8 antibody

ABCC8 Mouse IgG1 3E1 Purified Hu E, WB
0.1 mg / €360.00
  Abnova Taiwan Corp.

ABCC8 antibody

Human Small intestine; Small intestine; ABCC8 antibody - N-terminal region (ARP43622_P050) in Human Small intestine cells using Immunohistochemistry Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

ABCC8 antibody

Formalin-fixed and paraffin embedded mouse intestine labeled with Anti-SUR1 Polyclonal Antibody, Unconjugated (bs-3641R) at 1:200, followed by conjugation to the secondary antibody and DAB staining Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €240.00
  Bioss, Inc.

ABCC8 antibody

NBP1-00138 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ABCC8 antibody

Western Blot: SUR1 Antibody [NBP1-59778] - This Anti-ABCC8 antibody was used in Western Blot of 293T tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ABCC8

ABCC8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €370.00
  Abnova Taiwan Corp.

ABCC8

ABCC8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.

18 Item(s)

per page
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