ABL1 antibody

Principal name

ABL1 antibody

Alternative names for ABL1 antibody

c-ABL, p150, JTK7, bcr/abl, Proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1

SwissProt ID

P00519 (Human), P00520 (Mouse), Q61258 (Mouse)

Gene ID

25 (ABL1), 11350 (Abl1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of ABL1 antibody

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

General readings

1. Xu J  et al. c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin. Blood 115:2709-18 (2010). WB ; Human .
2. Jing Z  et al. Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis 17:409-22 (2009). WB, ICC/IF ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ABL1 antibody

  Rabbit polyclonal anti-ABL1 antibody  
Western blot analysis of extracts from 293 cells, using ABL1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit polyclonal ABL1 (Thr735) antibody(Phospho-specific)  
Western blot analysis of extracts from COS cells, treated with EGF (200ng/ml, 30mins), using ABL1 (Phospho-Thr735) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Anti-ABL1/ABL2 (phospho-Tyr393/429) Rabbit Polyclonal Antibody  
Predicted band size: 210 kDa . Positive control: HL60 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: HL60 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal Abl Antibody  
Western blot analysis of Abl expression in Adriamycin treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal c-Abl Antibody  
Western blot analysis of c-Abl expression in RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal c-Abl Antibody  
Western blot analysis of c-Abl expression in RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Phospho-ABL1/2 -Y393/429 Rabbit Polyclonal Antibody  
Western blot analysis of extracts from HL60 cells using phospho-ABL1/2 -Y393/429 antibody and the same antibody preincubated with blocking peptide. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal c-Abl Antibody  
Western Blot: c Abl Antibody [TA336552] - Detection of C-ABL in K562 whole cell lysate using TA336552. Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal Anti-ABL1 Antibody  
The image is immunohistochemistry of paraffin-embedded Human brain tissue using (ABL1 Antibody) at dilution 1/40. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

  Rabbit Polyclonal anti-c-Abl Antibody  
Human Placenta stained with anti-c-Abl antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ABL1 antibody

Western blot analysis using ABL1 antibody Cat.-No AM06256SU-N against truncated GST-ABL1 recombinant protein (1). Mouse IgG1 7B11D6 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

ABL1 pTyr134 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABL1 pTyr245 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABL1 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABL1 (N-term) antibody

Western blot analysis of ABL1 Antibody (N-term) in Y79 cell line lysates (35ug/lane). ABL1(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABL1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ABL1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ABL1 antibody

Western blot analysis of Abl  antibody (Cat.-No.: AP20341PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ABL1 antibody

Immunohistochemistry analysis of c-Abl antibody Cat.-No. AP20540PU-N in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ABL1 antibody

Immunohistochemistry analyzes of c-Abl antibody (Cat.-No.: AP20696PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ABL1 pTyr412 antibody

Immunohistochemistry analysis Phospho-Abl1 antibody (Cat.-No.: AP20872PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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