ACE / CD143 antibody

Principal name

ACE / CD143 antibody

Alternative names for ACE / CD143 antibody

DCP, DCP1, Angiotensin-converting enzyme, Dipeptidyl carboxypeptidase I

SwissProt ID

P09470 (Mouse), P12820 (Bovin), P12821 (Human), P12822 (Rabit), P47820 (Rat)

Gene ID

1636 (ACE), 100009274, 11421 (Ace)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Fe (Feline), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Gt (Goat), Sh (Sheep), Hst (Hamster)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP)

Background of ACE / CD143 antibody

Angiotensin I Converting Enzyme (ACE, also known as peptidyl-dipeptidase A, kininase II, or CD143) is a type I transmembrane zinc metallopeptidase that is important in the metabolism of the vaso-active peptides angiotensin II and bradykinin. Two isoforms of ACE that exhibit distinct physiologic functions have been described: germinally expressed ACE (gACE) and somatic cell expressed ACE (sACE). Both isoforms are transcribed from a single gene using alternative promoters. The gACE isoform is exclusively expressed in the testes, whereas sACE is expressed on endothelial cells, epithelial cells, neuronal cells, and dendritic cells. A soluble form of CD143 is likely shed from endothelial cells and is found in serum, plasma, seminal fluid, amniotic fluid and cerebral spinal fluid. Functionally, CD143 has a role in blood pressure regulation, electrolyte balance, reproduction, cardiovascular disease, kidney disease, cancer and Alzheimer’s disease. Inhibitors of ACE are used clinically to treat hypertension, cardiac failure, and diabetic retinopathy.

General readings

General / background references:Metzger R et al. CD143 in the development of atherosclerosis. Atherosclerosis 150:21-31 (2000). PubMed PMID: 10781632
Danilov S et al. Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site. J Biol Chem 269:26806-14 (1994). PubMed PMID: 7523412

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ACE / CD143 antibody

Predicted band size: 150kDa. Positive control: Mouse kidney tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 6%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1000 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ACE / CD143 antibody

Predicted band size: 150kDa. Positive control: Mouse kidney tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 6%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1000 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ACE / CD143 antibody

Western blot detection of Angiotensin Converting Enzyme 1 in Mouse kidney cell lysates using Angiotensin Converting Enzyme 1 mouse mAb (1:1000 diluted).Predicted band size:150KDa.Observed band size:190KDa. Mouse IgG2a 4F3-E6-H8 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ACE / CD143 antibody

Western blot analysis of ACE1 expression in mouse kidney Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ACE / CD143 (C-term) antibody

ACE / CD143 Mouse IgG1 12J16 Purified Hu WB
0.1 mg / €440.00
  Acris Antibodies GmbH

ACE / CD143 (C-term) antibody

Western blot analysis of anti-ACE Antibody (C-term) in mouse lung tissue lysates (35ug/lane). ACE (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ACE / CD143 antibody

Immunohistochemistry (IHC) analyzes of ACE1 antibody (Cat.-No.: AP20608PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 CG2 Purified Hu P
0.2 mg / €570.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Rat IgG2 9B21 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 3C5 Supernatant Hu P, WB
1 ml / €590.00
  Acris Antibodies GmbH

ACE / CD143 antibody

Staining of CHO cells  transfected with human CD143 (ACE) with SM1656F. Mouse IgG1 i2H5 FITC Hu F
0.1 mg / €470.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 i2H5 PE Hu F
100 Tests / €590.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 2E2 Supernatant Hu P, WB
1 ml / €590.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 9B9 Supernatant Hu C, E, F, IP
1 ml / €590.00
  Acris Antibodies GmbH

ACE / CD143 antibody

Staining of CHO cells transfected with Human CD143 (ACE) with SM1658F. Mouse IgG1 9B9 FITC Hu F
0.1 mg / €460.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 9B9 PE Hu F
100 Tests / €590.00
  Acris Antibodies GmbH

ACE / CD143 antibody

ACE / CD143 Mouse IgG1 i1A8 FITC Hu, Mky F
0.1 mg / €470.00
  Acris Antibodies GmbH

ACE / CD143 antibody

Detection limit for recombinant GST tagged ACE is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 6A4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ACE / CD143 antibody

Detection limit for recombinant GST tagged ACE is approximately 1ng/ml as a capture antibody. Mouse IgG1 4B10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ACE / CD143 antibody

Immunohistochemical analysis of CD143 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Sh P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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