Acetyl-CoA carboxylase 1 antibody

Principal name

Acetyl-CoA carboxylase 1 antibody

Alternative names for Acetyl-CoA carboxylase 1 antibody

ACACA, ACAC, ACC1, ACCA

SwissProt ID

P11497 (Rat), Q13085 (Human), Q5SWU9 (Mouse)

Gene ID

31 (ACACA), 60581 (Acaca)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Bov (Bovine), Por (Porcine), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C)

Background of Acetyl-CoA carboxylase 1 antibody

In cells, excess metabolic fuel is converted into fatty acids in cytosol and oxidized later in mitochondria to generate ATP and acetyl CoA. In fatty acid synthesis, catalytic formation of malonyl CoA from acetyl CoA by Acetyl CoA carboxylase (ACC1) is the rate limiting step. The translocation of LCFA CoA from cytosol to mitochondria is catalyzed by two carnitine palmitoyl transferases (CPT1 and CPT2) and regulated by ACC2, the rate limiting step of mitochondrial fatty acid beta oxidation. Activities of ACC1 and 2 are regulated by their phosphorylation by 5' AMP activated protein kinase (AMPK). Diabetes deranges AMPK master switch and represses the ACC1 gene expression and stimulates excessive fatty acid oxidation which in turn interferes with glucose metabolism. ACC1 is also known as ACC alpha and is a cytosolic enzyme, enriched in liver, adipose, and lactating mammary tissues. ACC1 catalyzes the carboxylation of acetyl CoA to form malonyl CoA, the rate limiting step in the biogenesis of LCFA CoA. ACC1 has three main functions acting as a biotin carboxyl carrier protein, a biotin carboxylase, and a carboxyltransferase (catalytic activity). Two variants of ACC1 have been described. One with 8 additional amino acids commencing at Pro 1196. The other, which is 59aa shorter than the predominant fat and liver isoform, exists in mammals. The presence of 8 additional amino acids inhibits the in vitro phosphorylation of the Ser1200 by cAMP dependent kinase. The two ACC1 isoforms are differentially regulated in a tissue specific manner and under different physiological conditions. The activity of ACC1 is finely regulated by hormone dependent phosphorylation and dephosphorylation.

General readings

Ray H. et al. Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.Biochemical and Biophysical Research Communications. Volume 378, Issue 3, 16 January 2009, Pages 615-619

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 28 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry-Paraffin: Acetyl Coenzyme A Carboxylase Alpha Antibody (EPR4971) [NBP1-95592] - Acetyl CoA Carboxylase 1 (ACC1). Rabbit EPR4971 Purified Hu, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Acetyl-CoA carboxylase 1 antibody

Western blot analysis of extracts from NIH/3T3 cells, treated with PMA (125ng/ml, 30mins), using ACC1 (Ab-80) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Acetyl-CoA carboxylase 1 antibody

Western blot analysis of extracts from NIH/3T3 cells treated with PMA (125ng/ml, 15min), using Acetyl-CoA Carboxylase (Ab-80) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Acetyl-CoA carboxylase 1 antibody

Predicted band size: 266 kDa . Positive control: Heia and HUVEC cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2: Heia and HUVEC cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Acetyl-CoA carboxylase 1 antibody

Western blot analysis of ACC1 expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry (IHC) analyzes of ACC1 antibody (Cat.-No.: AP06366PU-N) in paraffin-embedded human skeletal muscle brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry (IHC) analyzes of ACCA antibody (Cat.-No.: AP06367PU-N) in paraffin-embedded human breast carcinoma colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Acetyl-CoA carboxylase 1 pSer1263 antibody

Acetyl-CoA carboxylase 1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Acetyl-CoA carboxylase 1 antibody

Detection limit for recombinant GST tagged ACACA is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 6H5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Acetyl-CoA carboxylase 1 pSer80 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Acetyl-CoA Carboxylase (Phospho-Ser80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Acetyl-CoA carboxylase 1 pSer80 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Acetyl-CoA Carboxylase (Phospho-Ser80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Acetyl-CoA carboxylase 1 pSer80 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ACC1 (Phospho-Ser80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Acetyl-CoA carboxylase 1 pSer80 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ACC1 (Phospho-Ser80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Acetyl-CoA Carboxylase (Ab-80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Acetyl-CoA Carboxylase (Ab-80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using ACC1 (Ab-80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Acetyl-CoA carboxylase 1 antibody

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using ACC1 (Ab-80) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Acetyl-CoA carboxylase 1 antibody

Immunohistochemical analysis of ACC alpha staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt, Sh P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Acetyl-CoA carboxylase 1 antibody

Immunohistochemical analysis of ACC alpha staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt, Sh P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Acetyl-CoA carboxylase 1 antibody

Immunohistochemical analysis of ACC alpha staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt, Sh P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Items 1 to 20 of 28 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn