Acetylated Lysine antibody

Principal name

Acetylated Lysine antibody

Alternative names for Acetylated Lysine antibody

AcK, acetyl Lysine, acetyl-Lysine

Available reactivities

Hu (Human), All Species, Ms (Mouse), Av (Birds), Bov (Bovine), Mam (Mammalia)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Radioimmunoassay (R), Flow Cytometry (F), Paraffin Sections (P)

Background of Acetylated Lysine antibody

In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.
The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 deacetylases have been identified so far, but the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. Over 40 transcription factors and 30 other nuclear, cytoplasmic, bacterial, and viral proteins have been shown to be acetylated in vivo.

General readings

1. Yang XJ. (2005). Oncogene. 24:1653-1662.
2. Hassig, C.A. and Schreiber, S.L. (1997). Curr. Opin. Chem. Biol. 1(3): 300-308.
3. Yang XJ. (2004). Bioessays 26:1076-1087.
4. Hughes, R.E. (2002). Curr. Biol. 12: R141-R143.
5. Vigushin, D.M. and Coombes, R.C. (2004). Curr.
Cancer Drug Targets 4: 205-218.
6. Chan, H.M. et al. (2001). Nat. Cell Biol. 3: 667-674.
7. Martinez-Balbas, M.A. et al. (2000). EMBO J. 19: 662-671.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Acetylated Lysine antibody

Western blot analysis of the acetylated histone from TSA-treated mouse spleen cells. Rabbit IgG Aff - Purified E, ICC/IF, IP, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Acetylated Lysine antibody

Acetylated Lysine Mouse IgG1 7F8 Purified Av, Bov C, E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Acetylated Lysine antibody

Acetylated Lysine Mouse IgG1 7F8 Purified Av, Bov C, E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Acetylated Lysine antibody

Acetylated Lysine Rabbit IgG Biotin E, ICC/IF, IP, WB
0.4 ml / €430.00
  Acris Antibodies GmbH

Acetylated Lysine antibody

Acetylated Lysine Rabbit IgG HRP E, ICC/IF, IP, WB
0.4 ml / €450.00
  Acris Antibodies GmbH

Acetylated Lysine antibody

Acetylated Lysine Av
0.1 mg / €560.00
  Abnova Taiwan Corp.

Acetylated Lysine antibody

Acetylated Lysine Rabbit IgG Purified E, IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Acetylated Lysine antibody

Acetylated lysine polyclonal antibody ( Cat # PAB10348 ) is shown to detect Acetylated lysine in TSA-treated mouse spleen cell lysate ( Panel A ); control ( left lane ) and TSA-treated mouse spleen cell lysate ( right lane ) in panel B; and in acetylated BSA loaded as indicated ( panel C ). Rabbit IgG Hu C, E, F, ICC/IF, IP, R
0.1 mg / €560.00
  Abnova Taiwan Corp.

Acetylated Lysine antibody

Acetylated Lysine Rabbit HRP E, ICC/IF, IP, WB
0.4 ml / €470.00
  Novus Biologicals Inc.

Acetylated Lysine antibody

Western Blot: Acetylated Lysine Antibody (1C6) [NB100-74339] - Figure 1 illustrates Western blot detection of acetylated-lysine in HeLA cells using NB100-74339. Mouse IgG 1C6 Purified Hu, Ms ICC/IF, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Acetylated Lysine antibody

Immunofluorescence: Acetylated Lysine Antibody (15G10) [NB100-78428] - Untreated Hela cells (Upper Panel), or overnight nocodazole treated Hela cells (Lower Panel) stained with purified mouse monoclonal antibody against Acetylated Lysine (clone 15G10), followed by Rhodamine Red-X conjugated Donkey anti-mouse IgG and DAPI. Mouse IgG2b 15G10 Aff - Purified All Species ICC/IF, IP, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Acetylated Lysine antibody

Immunofluorescence: Acetylated Lysine (7F8) [NB110-96876] -  mouse backskin Mouse IgG1 7F8 Purified Av, Bov E, ICC/IF, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

Acetylated Lysine antibody

Acetylated Lysine Rabbit Biotin All Species E, ICC/IF, IP, WB
0.4 ml / €450.00
  Novus Biologicals Inc.

13 Item(s)

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