ACO1 / IREB1 antibody

Principal name

ACO1 / IREB1 antibody

Alternative names for ACO1 / IREB1 antibody

Aconitase, Iron regulatory protein 1, IRP1, Cytoplasmic aconitate hydratase, Citrate hydro-lyase, Iron-responsive element-binding protein 1, Ferritin repressor protein

SwissProt ID

P21399 (Human), P28271 (Mouse), Q01059 (Rabit), Q0VCU1 (Bovin), Q63270 (Rat), Q90875 (Chick)

Gene ID

48 (ACO1), 3500484 (P15711)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Rt (Rat), African clawed frog, Ms (Mouse), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of ACO1 / IREB1 antibody

The insulin receptor substrate-1 (IRS-1), a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.

General readings

Vashisht A.A., et al (2009) Science 326:718-721.
Salahudeen A.A., et al (2009) Science 326:722-726.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ACO1 / IREB1 antibody

WB Suggested Anti-ACO1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human kidney Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

ACO1 / IREB1 antibody

Human Capan1; . Sample Type :. Human Capan1 cells (Pancreatic cancer cell line). Primary Antibody Dilution :. 1:300. Secondary Antibody :. Anti-rabbit-AlexaFluor-488. Secondary Antibody Dilution :. 1:200. Color/Signal Descriptions :. ACO1: Green DAPI: Blue. Gene Name :. ACO1. Submitted by :. Dr. Pankaj Singh, UNMC, Omaha, NE; ACO1 antibody - N-terminal region (ARP40390_P050) in Human Capan1 cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Rb, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

ACO1 / IREB1 antibody

TA305638 (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ACO1 / IREB1 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and lung cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using ACO1 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ACO1 / IREB1 antibody

Predicted band size: 98 kDa. Positive control: Mouse liver tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ACO1 / IREB1 antibody

Immunohistochemistry analyzes of IRP-1 antibody in Paraffin-Embedded Human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

ACO1 / IREB1 antibody

Immunohistochemistry analyzes of IRP-1 antibody (Cat.-No.: AP20312PU-N) in paraffin-embedded human cervix carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ACO1 / IREB1 antibody

ACO1 MaxPab polyclonal antibody. Western Blot analysis of ACO1 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

ACO1 / IREB1 antibody

ACO1 MaxPab rabbit polyclonal antibody. Western Blot analysis of ACO1 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

ACO1 / IREB1 antibody

Detection limit for recombinant GST tagged ACO1 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 2C1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ACO1 / IREB1 antibody

ACO1 / IREB1 Mouse IgG2a 2F6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ACO1 / IREB1 pSer711 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland, using IREB1 (Phospho-Ser711) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

ACO1 / IREB1 pSer711 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland, using IREB1 (Phospho-Ser711) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

ACO1 / IREB1 pSer138 antibody

Immunohistochemistry analysis of paraffin-embedded human ovary, using IREB1 (Phospho-Ser138) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

ACO1 / IREB1 pSer138 antibody

Immunohistochemistry analysis of paraffin-embedded human ovary, using IREB1 (Phospho-Ser138) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

ACO1 / IREB1 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using IREB1 (Ab-711) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

ACO1 / IREB1 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using IREB1 (Ab-711) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

ACO1 / IREB1 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using IREB1 (Ab-138) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

ACO1 / IREB1 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using IREB1 (Ab-138) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

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