Activin receptor type 1 / ACRV1 antibody

Principal name

Activin receptor type 1 / ACRV1 antibody

Alternative names for Activin receptor type 1 / ACRV1 antibody

Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A, Serine/threonine-protein kinase receptor R1, Activin receptor-like kinase 2, TGF-B superfamily receptor type I

SwissProt ID

P37172 (Mouse), P80201 (Rat), Q04771 (Human), Q90ZK6 (Chick)

Gene ID

90 (ACVR1), 395246

Available reactivities

Hu (Human), Chk (Chicken), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat)

Available hosts

Mouse, Goat, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of Activin receptor type 1 / ACRV1 antibody

Activin, a disulfide-linked dimeric protein is secreted by Sertoli cells in the testis and grandulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of of the cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian betaA, betaB, betaC, betaE, and Xenopus betaD). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (betaA-betaA), activin B (betaB-betaB), activin AB (betaB-betaA), inhibin A (alpha-betaA), and inhibin B (alpha-betaB). Activins have a wide range of biological activities including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activin A is involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects of the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type II receptors. Activin type I and type II receptors are distinguished by the level of sequence homology of their kinase domains and other structural and functional features. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported. Type I activin receptors do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Activin receptor IA is highly conserved and will also bind to form signaling complexes with the BMP-2/7-bound BMPR-II. Human, mouse, and bovine type IA activin receptors share greater than 98 % homology.

General readings

Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS.
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.
Nat Genet. 2006 May;38(5):525-7. Epub 2006 Apr 23. Erratum in: Nat Genet. 2007
Feb;39(2):276. FOP International Research Consortium

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Activin receptor type 1 / ACRV1 antibody

TA303310 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 antibody

Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 antibody

Western blot using ALK-2 antibody on ALK-2 fusion protein. Sheep IgG Purified Chk IP, P, WB
0.25 mg / €360.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (475-509) antibody

Skeletal muscle, vessel: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (147-161) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with ACVR1 antibody AP22507PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (N-term) antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with ACVR1 antibody AP22653PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 Control Peptide

Activin receptor type 1 / ACRV1
50 µg / €160.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Activin receptor type 1 / ACRV1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

Activin receptor type 1 / ACRV1 Mouse IgG1 2D5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ACVR1 polyclonal antibody ( Cat # PAB2638 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ACVR1 polyclonal antibody ( Cat # PAB3474 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

ACVR1 polyclonal antibody ( 4µg/ml ) staining of paraffin embedded human testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

Western blot analysis using ACVR1 polyclonal antibody on ACVR1 fusion protein. Sheep Chk IP, P, WB
0.25 mg / €400.00
  Abnova Taiwan Corp.

Activin receptor type 1 / ACRV1 antibody

Human Muscle; ACVR1 antibody - N-terminal region (ARP45040_P050) in Human Muscle cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Activin receptor type 1 / ACRV1 (C-term) antibody

staining of Activin RIA (dilution: 4 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Neuromics Antibodies

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