Activin receptor type 1 / ACRV1 antibody

Principal name

Activin receptor type 1 / ACRV1 antibody

Alternative names for Activin receptor type 1 / ACRV1 antibody

Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A, Serine/threonine-protein kinase receptor R1, Activin receptor-like kinase 2, TGF-B superfamily receptor type I

SwissProt ID

P37172 (Mouse), P80201 (Rat), Q04771 (Human), Q90ZK6 (Chick)

Gene ID

90 (ACVR1), 395246, 11477 (Acvr1), 79558

Available reactivities

Hu (Human), Chk (Chicken), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Bt (Bat), Eq (Equine), Fi (Fish), Hst (Hamster), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Tr (Turkey), Bear, Mky (Monkey)

Available hosts

Mouse, Sheep, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Activin receptor type 1 / ACRV1 antibody

Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

General readings

Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS.
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.
Nat Genet. 2006 May;38(5):525-7. Epub 2006 Apr 23. Erratum in: Nat Genet. 2007
Feb;39(2):276. FOP International Research Consortium

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Activin receptor type 1 / ACRV1 antibody

  Goat Polyclonal Antibody against ACVR1  
TA303310 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 antibody

  Rabbit Polyclonal ACVR1 Antibody  
Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 antibody

  Rabbit Polyclonal Anti-ACVR1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (ACVR1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 antibody

Western blot using ALK-2 antibody on ALK-2 fusion protein. Sheep IgG Purified Chk IP, P, WB
0.25 mg / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (475-509) antibody

Skeletal muscle, vessel: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (147-161) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with ACVR1 antibody AP22507PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (N-term) antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with ACVR1 antibody AP22653PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 1 / ACRV1 (C-term) antibody

staining of Activin RIA (dilution: 4 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €420.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

ACVR1 - human gene knockout kit via CRISPR

ACVR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ACVR1 - human gene knockout kit via CRISPR

ACVR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ACVR1 - human gene knockout kit via CRISPR

ACVR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ACVR1 - human gene knockout kit via CRISPR

ACVR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Activin receptor type 1 / ACRV1 (transcript variant 1)

  Recombinant protein of human activin A receptor, type I (ACVR1), transcript variant 1  
Activin receptor type 1 / ACRV1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Activin receptor type 1 / ACRV1 (transcript variant 2)

  Recombinant protein of human activin A receptor, type I (ACVR1), transcript variant 2  
Activin receptor type 1 / ACRV1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ACVR1 (mGFP-tagged) - Human activin A receptor, type I (ACVR1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1 (mGFP-tagged) - Human activin A receptor, type I (ACVR1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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