Activin receptor type 1B / ACVR1B antibody

Principal name

Activin receptor type 1B / ACVR1B antibody

Alternative names for Activin receptor type 1B / ACVR1B antibody

ACTR-IB, ACVRLK4, ALK4, Activin receptor type IB, SKR2, Serine/threonine-protein kinase receptor R2, Activin receptor-like kinase 4

SwissProt ID

P36896 (Human), P80202 (Rat), Q61271 (Mouse)

Gene ID

91 (ACVR1B), 11479 (Acvr1b), 29381

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of Activin receptor type 1B / ACVR1B antibody

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand binding extracellular domain with a cysteine rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors.
Activin, a disulfide-linked homodimeric protein is secreted by Sertoli cells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian betaA, betaB, betaC, betaE, and Xenopus betaD). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (betaA-betaA), activin B (betaB-betaB), activin AB (betaB-betaA), inhibin A (alpha-betaA), and inhibin B (alpha- betaB).
Activins have a wide range of biological activities including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activins are also involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects ot the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type receptors. Activin type I and type II receptors are distinguished by the level of sequence homology of their kinase domains and other structural and functional features.

General readings

1. Peng Y  et al. Critical roles of miRNA-mediated regulation of TGFß signalling during mouse cardiogenesis. Cardiovasc Res 103:258-67 (2014). Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Activin receptor type 1B (ACVR1B) antibody

Activin receptor type 1B (ACVR1B) Rat IgG2 6J28 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Activin receptor type 1B / ACVR1B antibody

  Rabbit Polyclonal ACVR1B Antibody  
Western blot analysis of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

  Rabbit polyclonal anti-ACV1B antibody  
Western blot analysis of extracts from 293 cells and mouse liver cells, using ACV1B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

  Anti-ACVR1B rabbit polyclonal antibody  
Predicted band size: 57 kDa . Positive control: A172 cell lysate. Recommended dilution: 1/200-1000. (Gel: 6%SDS-PAGE Lysate: 80 ug per lane Primary antibody: 1/238 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 40 seconds) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

  Anti-ACVR1B Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human ovarian and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using ACVR1B antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

  Rabbit anti-ACVR1B Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ACVR1B antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

  Rabbit Polyclonal Anti-ACVR1B Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using (ACVR1B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 1B / ACVR1B antibody

Immunohistochemistry analysis of ACTR-IB Antibody (Cat.-No AP06686PU-N)  in Paraffin-Embedded Human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Activin receptor type 1B / ACVR1B (N-term) antibody

The anti-ACVR1B Pab is used in Western blot to detect ACVR1B in mouse kidney tissue lysate. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1B / ACVR1B antibody

The anti-ACVR1B Pab is used in Western blot to detect ACVR1B in Jurkat (1) and mouse kidney (2) tissue lysates. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 1B / ACVR1B antibody

Immunofluorescence analysis of HeLa cells, using ACV1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Activin receptor type 1B / ACVR1B antibody

Immunofluorescence analysis of HeLa cells, using ACV1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ACVR1B - human gene knockout kit via CRISPR

ACVR1B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

ACVR1B-knockout Cell lysate

ACVR1B-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ACVR1B (mGFP-tagged) - Human activin A receptor, type IB (ACVR1B), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (mGFP-tagged) - Human activin A receptor, type IB (ACVR1B), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ACVR1B (mGFP-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (mGFP-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, ACVR1B (mGFP-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (mGFP-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, ACVR1B (Myc-DDK tagged) - Human activin A receptor, type IB (ACVR1B), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (Myc-DDK tagged) - Human activin A receptor, type IB (ACVR1B), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, ACVR1B (Myc-DDK-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (Myc-DDK-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €980.00
  OriGene Technologies, Inc.

Lenti ORF particles, ACVR1B (Myc-DDK-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, ACVR1B (Myc-DDK-tagged)-Human activin A receptor, type IB (ACVR1B), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €980.00
  OriGene Technologies, Inc.

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