Activin receptor type 2A / ACVR2A antibody

Principal name

Activin receptor type 2A / ACVR2A antibody

Alternative names for Activin receptor type 2A / ACVR2A antibody

ACTR-IIA, ACTRIIA, Activin A receptor type IIA

SwissProt ID

P27037 (Human), P27038 (Mouse), P38444 (Rat)

Gene ID

92 (ACVR2A)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Goat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Neutralisation (NEUT), ELISA (detection) (E(detection))

Background of Activin receptor type 2A / ACVR2A antibody

Activin, a disulfide-linked homodimeric protein is secreted by Sertoli cells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian betaA, betaB, betaC, betaE, and Xenopus betaD). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (betaA-betaA), activin B (betaB-betaB), activin AB (betaB-betaA), inhibin A (alpha-betaA), and inhibin B (alpha- betaB). Activins have a wide range of biological activities including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activins are also involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects ot the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type receptors. Activin type I and type II receptors are distinguished by the level of sequence homology of their kinase domains and other structural and functional features. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splicevariants of activin receptor IIA and five splice variants of activin receptor IIB have been reported. Type I activin receptors are highly conserved and do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Type I activin receptors will also bind with the BMP-2/7-bound BMPR-II and form signaling complexes. Human, mouse, and bovine type IB activin receptors share greater than 98 % homology.

General readings

General / background references:de Winter JP et al. Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. Endocrinology 132:975-82 (1993). PubMed PMID: 7679985
Smith JC et al. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67:79-87 (1991). PubMed PMID: 1717160
de Jong FH et al. Effects of factors from ovarian follicular fluid and Sertoli cell culture medium on in-vivo and in-vitro release of pituitary gonadotrophins in the rat: an evaluation of systems for the assay of inhibin. J Reprod Fertil Suppl :47-59 (1979). PubMed PMID: 293411

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Activin receptor type 2A / ACVR2A antibody

Sample (30 ug of whole cell lysate). A: Hela. B: Hep G2 . 7.5% SDS PAGE. TA308578 diluted at 1:10000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 2A / ACVR2A antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human renal cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using ACVR2A antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 2A / ACVR2A antibody

Predicted band size: 58 kDa . Positive control: Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Activin receptor type 2A / ACVR2A antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACVR2A (RC210227, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ACVR2A.(1:500) Mouse IgG1 OTI8C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Activin receptor type 2A / ACVR2A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ACVR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807410) Mouse IgG1 OTI5D1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Activin receptor type 2A / ACVR2A (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 2A / ACVR2A antibody

Western blot (WB) analysis of ACTR-IIA antibody (Cat.-No.: AP20763PU-N) in extracts from rat kidney cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Activin receptor type 2A / ACVR2A (N-term) antibody

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Activin receptor type 2A / ACVR2A antibody

Western Blot analysis of ACVR2A expression in transfected 293T cell line by ACVR2A polyclonal antibody (A01).

Lane1:ACVR2A transfected lysate(57.848 KDa).
Lane2:Non-transfected lysate. Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Activin receptor type 2A / ACVR2A antibody

Activin receptor type 2A / ACVR2A Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Activin receptor type 2A / ACVR2A antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ACVR2A polyclonal antibody ( Cat # PAB2643 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Activin receptor type 2A / ACVR2A antibody

Activin receptor type 2A / ACVR2A Goat Aff - Purified Hu C, E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

Activin receptor type 2A / ACVR2A antibody

Activin receptor type 2A / ACVR2A Goat IgG Aff - Purified Hu E, NEUT, P, WB
25 µg / €360.00
  Novus Biologicals Inc.

Activin receptor type 2A / ACVR2A antibody

Western  Blot:  Activin A Receptor Type IIA Antibody [NBP1-33601] – Western blot analysis of Activin A Receptor Type IIA on Hela cells (Lane A) and Hep G2 lysates (Lane B) using NBP1-33601 at a dilution of 1:10000. Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Activin receptor type 2A / ACVR2A antibody

Immunohistochemistry-Paraffin: Activin A Receptor Type IIA Antibody [NBP1-91647] Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Activin receptor type 2A / ACVR2A

Activin receptor type 2A / ACVR2A Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Activin receptor type 2A / ACVR2A

Activin receptor type 2A / ACVR2A Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Activin receptor type 2A / ACVR2A

Activin receptor type 2A / ACVR2A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Activin receptor type 2A / ACVR2A

Activin receptor type 2A / ACVR2A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Activin receptor type 2A / ACVR2A

Activin receptor type 2A / ACVR2A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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