Activin receptor type 2B / ACVR2B antibody

Principal name

Activin receptor type 2B / ACVR2B antibody

Alternative names for Activin receptor type 2B / ACVR2B antibody

ACTR-IIB, ACTRIIB, Activin receptor type IIB

SwissProt ID

P27040 (Mouse), P38445 (Rat), Q13705 (Human)

Gene ID

93 (ACVR2B), 11481 (Acvr2b)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of Activin receptor type 2B / ACVR2B antibody

Activin, a disulfide-linked homodimeric protein is secreted by Sertolicells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian beta A, beta B, beta C, beta E, and Xenopus beta D). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (beta A-beta A), activin B (beta B-beta B), activin AB (beta B-beta A), inhibin A (alpha-beta A) abd inhibin B (alpha-beta B). Activins have a wide range of biological activities including mesoderm induction neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activins are also involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects of the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type II receptors. Activin type I and type II receptors are distinguished by the level of sequence homology of their kinase domains and other structural and functional features. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported. Type I activin receptors do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Recombinant soluble activin type II receptors bind activin with high affinity and are potent activin antagonists. Activin type II receptors are highly conserved and will also bind inhibin, BMP2, and BMP7 with lower affinities. Human, mouse, and rat type II activin receptors share 98 % homology.

General readings

General / background references:de Winter JP et al. Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. Endocrinology 132:975-82 (1993). PubMed PMID: 7679985
Smith JC et al. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67:79-87 (1991). PubMed PMID: 1717160
de Jong FH et al. Effects of factors from ovarian follicular fluid and Sertoli cell culture medium on in-vivo and in-vitro release of pituitary gonadotrophins in the rat: an evaluation of systems for the assay of inhibin. J Reprod Fertil Suppl :47-59 (1979). PubMed PMID: 293411

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Activin receptor type 2B / ACVR2B antibody

Hum. Fetal Liver; Host: Rabbit. Target Name: FAM46C . Sample Tissue: Human Fetal Liver . Antibody Dilution: 1.0ug/ml.; ACVR2B antibody - middle region (ARP45041_P050) in Hum. Fetal Liver cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Activin receptor type 2B / ACVR2B (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Activin receptor type 2B / ACVR2B antibody

ACVR2B polyclonal antibody (A01), Lot # 060717JCS1 Western Blot analysis of ACVR2B expression in 293 ( Cat # L026V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B antibody

Western Blot analysis of ACVR2B expression in transfected 293T cell line (H00000093-T02) by ACVR2B MaxPab polyclonal antibody.

Lane 1: ACVR2B transfected lysate(34.20 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B antibody

Immunoprecipitation of ACVR2B transfected lysate using anti-ACVR2B MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ACVR2B MaxPab mouse polyclonal antibody (B01) (H00000093-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B antibody

Western Blot analysis of ACVR2B expression in transfected 293T cell line by ACVR2B monoclonal antibody (M03), clone 1C11.

Lane 1: ACVR2B transfected lysate(57.724 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1C11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ACVR2B polyclonal antibody ( Cat # PAB2022 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B (Center) antibody

Human OVCAR-3; WB Suggested Anti-ACVR2B Antibody Titration: 0.2-1 ug/ml. Positive Control: OVCAR-3 cell lysate; ACVR2B antibody - middle region (ARP45042_P050) in Human OVCAR-3 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Activin receptor type 2B / ACVR2B antibody

Human HepG2; WB Suggested Anti-ACVR2B Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; ACVR2B antibody - C-terminal region (ARP45043_P050) in Human HepG2 cells using Western Blot Rabbit Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Activin receptor type 2B / ACVR2B antibody

Activin receptor type 2B / ACVR2B Goat IgG Aff - Purified Hu E, P, WB
25 µg / €380.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
50 µg / €139.00
  OriGene Technologies, Inc.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Activin receptor type 2B / ACVR2B

Activin receptor type 2B / ACVR2B Human
5 µg / €520.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

ACVR2B (Human) IP-WB Antibody Pair

ACVR2B (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ACVR2B overexpression lysate

ACVR2B overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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