ADAM15 / MDC15 antibody

Principal name

ADAM15 / MDC15 antibody

Alternative names for ADAM15 / MDC15 antibody

Metargidin, Disintegrin and metalloproteinase domain-containing protein 15, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, Metalloprotease RGD disintegrin protein

SwissProt ID

O88839 (Mouse), Q13444 (Human), Q9QYV0 (Rat)

Gene ID

8751 (ADAM15), 11490 (Adam15), 57025

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of ADAM15 / MDC15 antibody

ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

General readings

Zhong,J.L., (2008) Mol. Cancer Res. 6 (3), 383-394

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAM15 / MDC15 antibody

Western blot analysis of human fetal liver lysates with anti-ADAM15 antibody (diluted at 1:1000). The antibody identified a band of approximately 90kDa furin processed forms of ADAM15 and a 55kDa cleaved products in human fetal lier tissue lysates. The antibody also recognized a fainter band of ~110kDa (zymogen). Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

Predicted band size: 93 kDa . Positive control: Human liver cancer tissue, NIH/3T3 and Jurkat cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lane1: Human liver cancer tissue lysate Lane2: NIH/3T3 cell lysate Lane3: Jurkat cell lysate Lysates: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using ADAM15 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

WB Suggested Anti-ADAM15 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

Western blot analysis using Anti-ADAM15 Rabbit IgG Purified Hu WB
100 µl / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

Western blot of reduced glycoproteins from the indicated tissues which were probed with Anti-ADAM15 antibody. Rabbit IgG Purified Ms WB
100 µl / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

ADAM15 / MDC15 Rabbit IgG Purified Hu WB
100 µl / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

ADAM15 / MDC15 Rabbit IgG Purified Ms WB
100 µl / €325.00
  OriGene Technologies, Inc.

ADAM15 / MDC15 antibody

Western Blot analysis of ADAM15 expression in transfected 293T cell line (H00008751-T01) by ADAM15 MaxPab polyclonal antibody.

Lane 1: ADAM15 transfected lysate(84.92 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ADAM15 / MDC15 antibody

Mouse, Rat; rat and mouse brain; ADAM15 antibody - middle region (ARP46370_P050) in Mouse, Rat cells using Immunohistochemistry Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

ADAM15 - human gene knockout kit via CRISPR

ADAM15 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ADAM15 - human gene knockout kit via CRISPR

ADAM15 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAM15 / MDC15

ADAM15 / MDC15 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

ADAM15 / MDC15

ADAM15 / MDC15 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAM15 / MDC15

ADAM15 / MDC15 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ADAM15 / MDC15

ADAM15 / MDC15 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAM15 / MDC15

ADAM15 / MDC15 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ADAM15 293T Cell Transient Overexpression Lysate(Denatured)

ADAM15 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

ADAM15 overexpression lysate

ADAM15 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ADAM15 (mGFP-tagged)-Human ADAM metallopeptidase domain 15 (ADAM15), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ADAM15 (mGFP-tagged)-Human ADAM metallopeptidase domain 15 (ADAM15), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,680.00
  OriGene Technologies, Inc.

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