ADAM22 / MDC2 antibody

Principal name

ADAM22 / MDC2 antibody

Alternative names for ADAM22 / MDC2 antibody

Disintegrin and metalloproteinase domain-containing protein 22, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2, Metalloproteinase-disintegrin ADAM22-3

SwissProt ID

Q9P0K1 (Human), Q9R1V6 (Mouse)

Gene ID

11496 (Adam22), 53616 (ADAM22), 5361609 (accA)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ADAM22 / MDC2 antibody

ADAM22 was first described as MDC2 (Metalloproteinase-like disintergin like cysteine rich 2) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends have been described. ADAM22 participates in cell adhesion and spreading by associating with 14-3-3 proteins. It is constitutively produced in normal brain tissue, but decreased or absent in high grade gliomas. Different splice variants of ADAM22 are differentially expressed in areas of the brain. A complex of ADAM22 and LGI1 were shown to regulate synaptic transmission. Complexes of ADAM22, stargazing, and a range of other proteins anchor ADAM22 into the cytoskeleton, and keep ADAM22 in association with the postsynaptic space. ADAM22 does not contain the canonical HExxHxxxxxH zinc metalloproteinase motif, and is not thought to be proteolytically active. ADAM22 is a member of the ADAMS that function in tandem with other ADAMs and which may also have specific individual functions.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAM22 / MDC2 antibody

Transfected cell immunofluorescence showing unpermeabilized COS-1 cells expressing ADAM22. Mouse IgG1 N57/2 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

ADAM22 / MDC2 antibody

Transfected cell immunofluorescence showing unpermeabilized COS-1 cells expressing ADAM22. Mouse IgG1 N57/2 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

ADAM22 / MDC2 (757-857, Cytpl. Dom.) antibody

WB of rat brain membrane lysate showing the detection of ~90 kDa ADAM22 protein using Anti-ADAM22 antibody. Lane 1: MW ladder. Lane 2: Anti-ADAM22 (1:100). Load: 20 µg RBM per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-ADAM22 monoclonal antibody incubated for 60 min at RT. Secondary antibody: Goat Anti-Mouse HRP antibody at 1:50 for 83 min at RT. Colour Development: TMB solution for 10 min at RT. Mouse IgG2b S46-30 Purified Ms, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ADAM22 / MDC2 (444-526, Extracell. Dom.) antibody

WB of rat brain lysates showing the detection of ~90 kDa ADAM22 protein using Anti-ADAM22 antibody.  Lane 1: MW ladder. Lane 2: Anti-ADAM22 (1:250). Lane 3: Anti-ADAM22 (1:500).  Lane 4: Anti-ADAM22 (1:1000) Load: 20 µg RB per lane. Block: 5% milk + TBST O/N at 4°C. Primary antibody: Mouse Anti-ADAM22 monoclonal antibody incubated for 60 min at RT. Secondary antibody: Goat Anti-Mouse HRP antibody at 1:50 for 83 min at RT. Colour Development: TMB solution for 55 min at RT. Predicted/Observed size: ~ 90 kDa. Other band(s):~25kDa, ~35Kda. Mouse IgG1 S57-2 Purified Ms, Rt ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ADAM22 / MDC2 antibody

WB Suggested Anti-Adam22 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Mouse Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ADAM22 / MDC2 (Cytoplasm.) antibody

Adult rat brain membrane immunoblot Mouse IgG2b N46/30 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

ADAM22 / MDC2 (Cytoplasm.) antibody

Adult rat brain membrane immunoblot Mouse IgG2b N46/30 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

ADAM22 / MDC2 antibody

ADAM22 / MDC2 Rabbit Serum Hu, Ms, Rt C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

ADAM22 / MDC2 antibody

ADAM22 / MDC2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

ADAM22 / MDC2 (N-term) antibody

ADAM22 / MDC2 Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

ADAM22 / MDC2 antibody

ADAM22 / MDC2 Rabbit Serum Ms, Rt P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

ADAM22 / MDC2 antibody

Western Blot: ADAM22 Antibody [NBP1-69015] Rabbit Aff - Purified Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAM22 / MDC2

ADAM22 / MDC2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAM22 / MDC2

ADAM22 / MDC2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ADAM22 293T Cell Transient Overexpression Lysate(Denatured)

ADAM22 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

15 Item(s)

per page
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