ADAMTS13 antibody

Principal name

ADAMTS13 antibody

Alternative names for ADAMTS13 antibody

ADAMTS-13, ADAM-TS13, C9orf8, vWF-cleaving protease, A disintegrin and metalloproteinase with thrombospondin motifs 13, von Willebrand factor-cleaving protease

SwissProt ID

Q769J6 (Mouse), Q76LX8 (Human)

Gene ID

11093 (ADAMTS13)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of ADAMTS13 antibody

ADAMTS-13 is produced by hepatic stellate cells and in smaller amounts by human endothelial cells, and is present in plasma at a concentration of approximately 1 µg/ml.
ADAMTS-13 is a zinc-containing metalloprotease belonging to the ADAMTS family characterized by a protease domain, an adjacent disintegrin-like domain, one or more thrombospondin type 1 repeats, a cystein-rich domain and a typical spacer region. ADAMTS-13 is composed of a series of domains (amino to carboxy terminal): metalloprotease, disintegrin-like, central thrombospondin-1 (TSP-1), cysteine-rich, spacer, seven additional TSP-1 domains and two unique CUB domains. ADAMTS-13 has no hydrophobic transmembrane domain, and hence it is not anchored in the cell membrane. The apparent molecular weight is 170 or 190 kDa on non-reducing or reducing SDS-PAGE, respectively.
ADAMTS-13 has an important function in haemostasis, where it catalyzes the cleavage of the peptide bond between tyrosine-1605 and methionine-1606 in the A2 domain of von Willebrand Factor (VWF), resulting in 2 electrophoretic reduced fragments of 176 and 140 kDa, respectively. This process renders large multimers less adhesive and hence less reactive in the setting of thrombus formation. ADAMTS-13 is therefore said to be a natural anti-thrombotic agent.
Severe ADAMTS-13 deficiency is associated with systemic microvascular thrombosis in familial or acquired thrombotic thrombocytopenic purpura (TTP). The accumulation of non-cleaved large VWF multimers causes spontaneous systemic platelet aggregation blocking oxygen supply to vital organs. This life-threatening disorder can lead to ischemic disease with (multiple) organ failure.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAMTS13 (686-894) antibody

ADAMTS13 Mouse IgG1 20A5 Purified Hu E, ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

ADAMTS13 (686-894) antibody

ADAMTS13 Mouse IgG1 5C11 Purified Hu E, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

ADAMTS13 antibody

Immunohistochemistry: AP14085PU-N ADAMTS13 antibody staining of Formalin-Fixed Paraffin-Embedded Human hepatocarcinoma followed by peroxidase-conjugation to the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ADAMTS13 antibody

ADAMTS13 Rabbit Serum Hu, Ms C, E, P, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

ADAMTS13 antibody

ADAMTS13 polyclonal antibody (A01), Lot # 051109JC01 Western Blot analysis of ADAMTS13 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ADAMTS13 antibody

Detection limit for recombinant GST tagged ADAMTS13 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 4F12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

ADAMTS13 antibody

Western Blot: ADAM-TS13 Antibody [NB100-584] - Detection of Recombinant Human Adam-TS13 by Western Blot. Purified recombinant Adam-TS13. NB100-584 used at the indicated concentrations. Rabbit Aff - Purified Hu WB
0.1 ml / €440.00
  Novus Biologicals Inc.

ADAMTS13 antibody

WB and IP: ADAMTS13 Antibody [NB100-55261] - Detection of Human ADAMTS13 on HeLa whole cell lysates using NB100-55259, NB100-55260, NB100-55261 and NB100-55262. For blotting IPed ADAMTS13, goat anti-ADAMTS13 antibody A300-002A was used. Goat Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

ADAMTS13 antibody

WB and IP: ADAMTS13 Antibody [NB100-55262] - Detection of Human ADAMTS13 on HeLa whole cell lysates using NB100-55259, NB100-55260, NB100-55261 and NB100-55262. For blotting IPed ADAMTS13, goat anti-ADAMTS13 antibody A300-002A was used. Goat Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

ADAMTS13 antibody

ADAMTS13 Rabbit Serum Hu, Ms E, P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAMTS13 (transcript variant 1)

ADAMTS13 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ADAMTS13

ADAMTS13 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ADAMTS13 overexpression lysate

ADAMTS13 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

16 Item(s)

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