ADAMTS13 antibody

Principal name

ADAMTS13 antibody

Alternative names for ADAMTS13 antibody

ADAMTS-13, ADAM-TS13, C9orf8, vWF-cleaving protease, A disintegrin and metalloproteinase with thrombospondin motifs 13, von Willebrand factor-cleaving protease

SwissProt ID

Q769J6 (Mouse), Q76LX8 (Human)

Gene ID

11093 (ADAMTS13), 279028 (Adamts13)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of ADAMTS13 antibody

ADAMTS-13 is produced by hepatic stellate cells and in smaller amounts by human endothelial cells, and is present in plasma at a concentration of approximately 1 µg/ml.
ADAMTS-13 is a zinc-containing metalloprotease belonging to the ADAMTS family characterized by a protease domain, an adjacent disintegrin-like domain, one or more thrombospondin type 1 repeats, a cystein-rich domain and a typical spacer region. ADAMTS-13 is composed of a series of domains (amino to carboxy terminal): metalloprotease, disintegrin-like, central thrombospondin-1 (TSP-1), cysteine-rich, spacer, seven additional TSP-1 domains and two unique CUB domains. ADAMTS-13 has no hydrophobic transmembrane domain, and hence it is not anchored in the cell membrane. The apparent molecular weight is 170 or 190 kDa on non-reducing or reducing SDS-PAGE, respectively.
ADAMTS-13 has an important function in haemostasis, where it catalyzes the cleavage of the peptide bond between tyrosine-1605 and methionine-1606 in the A2 domain of von Willebrand Factor (VWF), resulting in 2 electrophoretic reduced fragments of 176 and 140 kDa, respectively. This process renders large multimers less adhesive and hence less reactive in the setting of thrombus formation. ADAMTS-13 is therefore said to be a natural anti-thrombotic agent.
Severe ADAMTS-13 deficiency is associated with systemic microvascular thrombosis in familial or acquired thrombotic thrombocytopenic purpura (TTP). The accumulation of non-cleaved large VWF multimers causes spontaneous systemic platelet aggregation blocking oxygen supply to vital organs. This life-threatening disorder can lead to ischemic disease with (multiple) organ failure.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAMTS13 (686-894) antibody

ADAMTS13 Mouse IgG1 20A5 Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

ADAMTS13 (686-894) antibody

ADAMTS13 Mouse IgG1 5C11 Purified Hu E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

ADAMTS13 antibody

Immunohistochemistry: AP14085PU-N ADAMTS13 antibody staining of Formalin-Fixed Paraffin-Embedded Human hepatocarcinoma followed by peroxidase-conjugation to the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ADAMTS13 antibody

ADAMTS13 Rabbit Serum Hu, Ms C, E, P, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

ADAMTS13 antibody

ADAMTS13 polyclonal antibody (A01), Lot # 051109JC01 Western Blot analysis of ADAMTS13 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ADAMTS13 antibody

Detection limit for recombinant GST tagged ADAMTS13 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 4F12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

ADAMTS13 - human gene knockout kit via CRISPR

ADAMTS13 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ADAMTS13 - human gene knockout kit via CRISPR

ADAMTS13 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADAMTS13 - human gene knockout kit via CRISPR

ADAMTS13 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADAMTS13 - human gene knockout kit via CRISPR

ADAMTS13 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adamts13 - mouse gene knockout kit via CRISPR

Adamts13 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Adamts13 - mouse gene knockout kit via CRISPR

Adamts13 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adamts13 - mouse gene knockout kit via CRISPR

Adamts13 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adamts13 - mouse gene knockout kit via CRISPR

Adamts13 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAMTS13 (transcript variant 1)

  Recombinant protein of human ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 1  
ADAMTS13 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ADAMTS13

ADAMTS13 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS13

ADAMTS13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ADAMTS13 overexpression lysate

ADAMTS13 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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