ADAMTS3 antibody

Principal name

ADAMTS3 antibody

Alternative names for ADAMTS3 antibody

ADAMTS-3, ADAM-TS3, KIAA0366, A disintegrin and metalloproteinase with thrombospondin motifs 3, Procollagen II amino propeptide-processing enzyme, Procollagen II N-proteinase

SwissProt ID

O15072 (Human)

Gene ID

9508 (ADAMTS3)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of ADAMTS3 antibody

ADAMTS3 is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS3 (A Disintegrin And Metalloproteinase with ThromboSpondin 3 motif was first described in human brain. Human ADAMTS3 is 61% identical to human ADAMTS2. Both ADAMTS2 and ADAMTS3 have the ability to process procollagen II, but it is suggested that ADAMTS3 is the majorprocollagen II N-propeptidase. ADAMTS3 expression is found in placenta, cartilage, skin, lung, brain, and heart. Full length human ADAMTS3 contains 1201 amino acids and has a predicted mass of 135kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS3 a greater apparent molecular weight on reduced SDS-PAGE gels. Purified ADAMTS3 resolves at a lower molecular weight of 108 kDa, due to cleavage at the furin site. ADAMTS3 contains the canonical HexxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active, cleaving procollagen II. In addition to the metalloprotease domain, ADAMTS3 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, and three thrombospondin-1 like domains, followed by a C-terminal domain unique to ADAMTS2 and ADAMTS3. ADAMTS3 does not have a transmembrane domain, unlike many of the ADAMs proteases, and is a secreted protein, much of which binds to the ECM (extracellular matrix).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAMTS3 antibody

Western blot analysis of human fetal heart (Lane 1) and brain (Lane 2) lysates with anti-ADAMTS3 antibody (1:2000). This antibody identified zymogen form of ADAMTS3 at 140kDa, and activated forms at 94-105kDa. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAMTS3 antibody

ADAMTS3 Mouse IgG2a 1D6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ADAMTS3 antibody

ADAMTS3 Mouse IgG2a 1D6 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

ADAMTS3 antibody

ADAMTS3 Mouse IgG1 1H8 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAMTS3

ADAMTS3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ADAMTS3

ADAMTS3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS3

ADAMTS3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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