ADAMTS5 antibody

Principal name

ADAMTS5 antibody

Alternative names for ADAMTS5 antibody

ADAMTS-5, ADAM-TS5, ADAMTS11, ADMP2, Aggrecanase-2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 5

SwissProt ID

Q9R001 (Mouse), Q9TT92 (Bovin), Q9UNA0 (Human)

Gene ID

11096 (ADAMTS5)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey), Bear, Bt (Bat), Can (Canine), Chk (Chicken), Eq (Equine), Hst (Hamster), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of ADAMTS5 antibody

ADAMTS5, also known as Implantin or Aggrecanase 2, is a member of the larger family of ADAM (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin-5 motif) was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human and mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, and numerous other tissues, as well as chondroblastoma cell lines. Initial observations indicated a role for ADAMTS5 in aggrecan cleavage and cartilage destruction, especially in arthritis, and potentially a role in embryo implantation. ADAMTS5 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to efficiently cleave Aggrecan. In addition to the metalloprotease domain, ADAMTS5 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, a spacer domain, and two thrombospondin-1 like domains. ADAMTS5 is inhibited by the endogenous MMP inhibitors (TIMP1, 2, 3, and 4) but most efficiently by TIMP3. Unlike many of the ADAMs proteases, ADAMTS5 does not have a transmembrane domain, and is a secreted protein. Full length ADAMTS5 is a 930 amino acid protein with a predicted molecular mass is 101.7 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS5 a greater apparent molecular weight on reduced SDS PAGE gels. When ADAMTS5 is secreted, it is cleaved at the furin cleavage site (predicted molecular mass 73.2 kDa) and then further cleaved to generate a range of smaller forms.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAMTS5 antibody

Western blot analysis of human fetal brain lysates with anti-ADAMTS5 antibody (1:500). This antibody identified a band of 72kDa and a breakdown product at 50kDa in human fetal brain tissue lysates. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Predicted band size: 102kDa. Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/650 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 3 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human lung cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using ADAMTS5 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAMTS5 (C-term) antibody

Anti-ADAMTS5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

ADAMTS5 Rabbit Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 (N-term) antibody

Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Hu, Mky, Por P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Hu, Mky, Ms, Por, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Bt, Can, Hst, Hu, Por, Rb P
50 µg / €379.00
  OriGene Technologies, Inc.

ADAMTS5 antibody

Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscle tissue lysates (35ug/lane). ADAMTS5(arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ADAMTS5 antibody

ADAMTS5 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

ADAMTS5 antibody

ADAMTS5 Rabbit Aff - Purified Bov, Hu, Por WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ADAMTS5 antibody

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP1-89247] Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in glial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAMTS5

ADAMTS5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS5

ADAMTS5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ADAMTS5

ADAMTS5 Human
5 µg / €450.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ADAMTS5 overexpression lysate

ADAMTS5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

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