ADAMTS8 / METH2 antibody

Principal name

ADAMTS8 / METH2 antibody

Alternative names for ADAMTS8 / METH2 antibody

ADAMTS-8, ADAM-TS8, METH-2, METH-8, A disintegrin and metalloproteinase with thrombospondin motifs 8

SwissProt ID

P57110 (Mouse), Q9UP79 (Human)

Gene ID

11095 (ADAMTS8)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ADAMTS8 / METH2 antibody

ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ADAMTS8 / METH2 antibody

Western blot analysis of extracts from fetal liver using ADAMTS8 antibody diluted at 1:1000. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ADAMTS8 / METH2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ADAMTS8 (RC212446, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ADAMTS8. Mouse IgG2b OTI2A5 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

ADAMTS8 / METH2 antibody

Anti-ADAMTS8 mouse monoclonal antibody (TA505684) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ADAMTS8(RC212446). Mouse IgG1 OTI2H5 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ADAMTS8 / METH2 antibody

Detection limit for recombinant GST tagged ADAMTS8 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 5A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ADAMTS8 / METH2

ADAMTS8 / METH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ADAMTS8 / METH2

ADAMTS8 / METH2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ADAMTS8 / METH2

ADAMTS8 / METH2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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