Adenosine receptor A2a antibody

Principal name

Adenosine receptor A2a antibody

Alternative names for Adenosine receptor A2a antibody

ADORA2A, ADORA2

SwissProt ID

P11617 (Canfa), P29274 (Human), P30543 (Rat), Q60613 (Mouse)

Gene ID

135 (ADORA2A), 134 (ADORA1), 11540

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of Adenosine receptor A2a antibody

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions of many tissues including brain and heart. Adenosine exerts its action via four specific adenosine receptors (also med P1 purinergic receptors): A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and are members of the G protein-coupled receptor superfamily, which share a common structure of seven putative transmembrane domains, an extracellular NH2 terminus, cytoplasmic COOH terminus, and a third intracellular loop important for binding G proteins. The adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine alogs. Adenosine receptors control neurotransmitter release through the facilitatory A2AAR and the inhibitory A1AR. A2AAR and A1AR are the major adenosine receptor subtypes expressed in the central nervous system (CNS). A2AAR is mainly expressed in the striatum on GABAergic striatopallidal neurons, while A1AR is widely distributed throughout the CNS. A2AAR was suggested to play a critical role in attenuation of systemic inflammatory responses and prevention of extensive tissue damage. It was suggested that extracellular adenosine that accumulates in inflamed and damaged tissue may activate the A2AAR expressed in immune cells leading to termition/inhibition of the immune response. It was further suggested that this same mechanism may protect tumors from antitumor T cells through an immunosuppressive sigl generated by the activation of A2AAR on T cells by extracellular adenosine produced from hypoxic cancerous tissues.

General readings

General / background references:Olah ME & Stiles GL Adenosine receptor subtypes: characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol 35:581-606 (1995). PubMed PMID: 7598508
Palmer TM & Stiles GL Adenosine receptors. Neuropharmacology 34:683-94 (1995). PubMed PMID: 8532135

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenosine receptor A2a (C-term) antibody

Adenosine receptor A2a Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Adenosine receptor A2a antibody

Sample (30 ug of whole cell lysate). A: Hela. B: Molt-4 . 10% SDS PAGE. TA308729 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TA308730 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Western blot analysis of RAEC (lanes 1,3), rat brain (lanes 2,4) and Jurkat (lanes 5,6) lysates: 1,2,5. Anti-A2A Adenosine Receptor antibody, (1:200). 3,4,6. Anti-A2A Adenosine Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Flow cytometry on ADORA2A transfected HEK283F cells. Aqua and blue graphs are negative controls. The red and black graphs are the ADORA2A antibody stained cells. Mouse IgG2a 864H2 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Flow cytometry on ADORA2A transfected HEK283F cells. Aqua and blue graphs are negative controls. The red and black graphs are the ADORA2A antibody stained cells. Mouse IgG2a 864H3 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Flow cytometry on ADORA2A transfected HEK283F cells. Aqua and blue graphs are negative controls. The red and black graphs are the ADORA2A antibody stained cells. Mouse IgG1 864H9 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Flow cytometry on ADORA2A transfected HEK283F cells. Aqua and blue graphs are negative controls. The red and black graphs are the ADORA2A antibody stained cells. Mouse IgG2a 864H14 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a antibody

Flow cytometry on ADORA2A transfected HEK283F cells. Aqua and blue graphs are negative controls. The red and black graphs are the ADORA2A antibody stained cells. Mouse IgG2a 864H17 Purified Hu F
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenosine receptor A2a (full length) antibody

AM12133PU-N ADORA2A antibody staining of Formalin-Fixed Paraffin-Embedded Human Brain, Putamen at 5 µg/ml after heat-induced antigen retrieval. Mouse IgG2a 7F6-G5-A2 / 7F6 Purified Can, GP, Hu, Ms, Rb, Rt F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Adenosine receptor A2a antibody

Immunohistochemistry analysis of Adenosine A2A-R Antibody (Cat.-No AP01259PU-N) in paraffin-embedded human skeleta l muscle tissue. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Adenosine receptor A2a (Center) antibody

Confocal immunofluorescent analysis of ADORA2A Antibody (Center) (Cat#AP50096PU-N) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Aff - Purified Hu ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Adenosine receptor A2a antibody

ADORA2A MaxPab polyclonal antibody. Western Blot analysis of ADORA2A expression in HeLa. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

ADORA2A MaxPab polyclonal antibody. Western Blot analysis of ADORA2A expression in HeLa. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

Western Blot analysis of ADORA2A expression in transfected 293T cell line (H00000135-T03) by ADORA2A MaxPab polyclonal antibody.

Lane 1: ADORA2A transfected lysate(45.32 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

ADORA2A MaxPab rabbit polyclonal antibody. Western Blot analysis of ADORA2A expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

Adenosine receptor A2a Mouse IgG1 4E4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

Adenosine receptor A2a Goat Mky E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Adenosine receptor A2a antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADORA2A Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

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