Adenylate cyclase type 1 antibody

Principal name

Adenylate cyclase type 1 antibody

Alternative names for Adenylate cyclase type 1 antibody

ADCY1, Adenylate cyclase type I, ATP pyrophosphate-lyase 1, Adenylyl cyclase 1, Ca(2+)/calmodulin-activated adenylyl cyclase

SwissProt ID

O88444 (Mouse), P19754 (Bovin), Q08828 (Human)

Gene ID

107 (ADCY1), 432530 (Adcy1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Adenylate cyclase type 1 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors. Nine human AC isoforms (AC-1 through AC-9), encoded by separate genes, have been identified up to now (1). Most of the adenylate cyclase genes are comprise of 11-26 exons and distributed over a q6-430 kb. Majority of the adenylate cyclases previously described are expressed discretely in defined peripheral tissues, the type 1 adenylate cyclase (AC-1) is localized on chromosome 11, expressed predominantly in brain and is sensitive to Ca/Calmodulin stimulation. Genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. All, but AC-9, are activated by Forskolin and GTP bound Gs reported. The type I Ca(2+)-sensitive adenylyl cyclase has been implicated in several forms of synaptic plasticity in vertebrates, mutations in the AC-1 gene led to deficits in learning and memory (2). Mutant mice in which this enzyme was inactivated by targeted mutagenesis show deficient spatial memory and altered long-term potentiation (3). During first two weeks of postnatal development, there is significant increase in AC-1 mRNA and enzymatic activity in hippocampus, cerebellum and cortex that corresponds to appearance of long-term potentiation which supports the notion that AC-1 activity is important for neuronal plasticity and spatial memory (4).

General readings

1. Tekmen M & Gleason E Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells. J Neurophysiol 104:1849-66 (2010). WB ; Chicken .

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 1 antibody

  Rabbit polyclonal anti-ADCY1 antibody  
Western blot analysis of extracts from COLO205 cells, using ADCY1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 antibody

  Anti-ADCY1 rabbit polyclonal antibody  
Predicted band size: 123kDa. Positive control: 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1000 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 antibody

  Anti-ADCY1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human colon and liver cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using ADCY1 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 Control Peptide

Adenylate cyclase type 1
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 (C-term) antibody

Adenylate cyclase type 1 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 (aa 230-280) antibody

Immunohistochemistry (IHC) analyzes of A Cyclase I antibosy (Cat.-No.: AP20473PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 antibody

Western blot analysis of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

Adenylate cyclase type 1 antibody

Western blot analysis of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ADCY1 - human gene knockout kit via CRISPR

ADCY1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ADCY1 - human gene knockout kit via CRISPR

ADCY1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADCY1 - human gene knockout kit via CRISPR

ADCY1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADCY1 - human gene knockout kit via CRISPR

ADCY1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy1 - mouse gene knockout kit via CRISPR

Adcy1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Adcy1 - mouse gene knockout kit via CRISPR

Adcy1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy1 - mouse gene knockout kit via CRISPR

Adcy1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy1 - mouse gene knockout kit via CRISPR

Adcy1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ADCY1 (mGFP-tagged) - Human adenylate cyclase 1 (brain) (ADCY1), 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY1 (mGFP-tagged) - Human adenylate cyclase 1 (brain) (ADCY1), 200 uL, >10^7 TU/mL  
200 µl / €2,240.00
  OriGene Technologies, Inc.

Lenti ORF particles, ADCY1 (Myc-DDK tagged) - Human adenylate cyclase 1 (brain) (ADCY1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY1 (Myc-DDK tagged) - Human adenylate cyclase 1 (brain) (ADCY1) , 200 uL, >10^7 TU/mL  
200 µl / €2,020.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Adcy1 (GFP-tagged) - Mouse adenylate cyclase 1 (Adcy1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adcy1 (GFP-tagged) - Mouse adenylate cyclase 1 (Adcy1), 200 uL, >10^7 TU/mL  
200 µl / €1,930.00
  OriGene Technologies, Inc.

Lenti ORF particles, Adcy1 (Myc-DDK-tagged) - Mouse adenylate cyclase 1 (Adcy1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adcy1 (Myc-DDK-tagged) - Mouse adenylate cyclase 1 (Adcy1), 200 uL, >10^7 TU/mL  
200 µl / €1,740.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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