Adenylate cyclase type 1 antibody

Principal name

Adenylate cyclase type 1 antibody

Alternative names for Adenylate cyclase type 1 antibody

ADCY1, Adenylate cyclase type I, ATP pyrophosphate-lyase 1, Adenylyl cyclase 1, Ca(2+)/calmodulin-activated adenylyl cyclase

SwissProt ID

O88444 (Mouse), P19754 (Bovin), Q08828 (Human)

Gene ID

107 (ADCY1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Adenylate cyclase type 1 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors. Nine human AC isoforms (AC-1 through AC-9), encoded by separate genes, have been identified up to now (1). Most of the adenylate cyclase genes are comprise of 11-26 exons and distributed over a q6-430 kb. Majority of the adenylate cyclases previously described are expressed discretely in defined peripheral tissues, the type 1 adenylate cyclase (AC-1) is localized on chromosome 11, expressed predominantly in brain and is sensitive to Ca/Calmodulin stimulation. Genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. All, but AC-9, are activated by Forskolin and GTP bound Gs reported. The type I Ca(2+)-sensitive adenylyl cyclase has been implicated in several forms of synaptic plasticity in vertebrates, mutations in the AC-1 gene led to deficits in learning and memory (2). Mutant mice in which this enzyme was inactivated by targeted mutagenesis show deficient spatial memory and altered long-term potentiation (3). During first two weeks of postnatal development, there is significant increase in AC-1 mRNA and enzymatic activity in hippocampus, cerebellum and cortex that corresponds to appearance of long-term potentiation which supports the notion that AC-1 activity is important for neuronal plasticity and spatial memory (4).

General readings

1. Tekmen M & Gleason E Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells. J Neurophysiol 104:1849-66 (2010). WB ; Chicken .

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 1 antibody

Western blot analysis of extracts from COLO205 cells, using ADCY1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 antibody

Predicted band size: 123kDa. Positive control: 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1000 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and liver cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using ADCY1 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 1 Control Peptide

Adenylate cyclase type 1
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 (C-term) antibody

Adenylate cyclase type 1 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 (aa 230-280) antibody

Immunohistochemistry (IHC) analyzes of A Cyclase I antibosy (Cat.-No.: AP20473PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Adenylate cyclase type 1 antibody

Western blot analysis of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

Adenylate cyclase type 1 antibody

Western blot analysis of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

Adenylate cyclase type 1 antibody

Immunohistochemical analysis of Adenylate Cyclase 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Adenylate cyclase type 1 antibody

Immunohistochemical analysis of Adenylate Cyclase 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Adenylate cyclase type 1 antibody

Immunohistochemical analysis of Adenylate Cyclase 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Adenylate cyclase type 1 antibody

Immunohistochemistry: A Cyclase I Antibody [NBP1-19628] -  A Cyclase I Antibody [NBP1-19628] - paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Adenylate cyclase type 1 antibody

Adenylate cyclase type 1 Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Adenylate cyclase type 1 antibody

Adenylate cyclase type 1 Rabbit IgG Aff - Purified Hu, Ms E, WB
50 µg / €290.00
  Novus Biologicals Inc.

14 Item(s)

per page
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