Adenylate cyclase type 2 antibody

Principal name

Adenylate cyclase type 2 antibody

Alternative names for Adenylate cyclase type 2 antibody

ADCY2, KIAA1060, Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2

SwissProt ID

P26769 (Rat), Q08462 (Human), Q80TL1 (Mouse)

Gene ID

108 (ADCY2), 1084159 (Q81UJ9)

Available reactivities

Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Adenylate cyclase type 2 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gsa to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 2 antibody

Western blot analysis of human fetal brain tissue extracts with anti-ADCY2 antibody (1:500). This antibody identified a band of ~125kDa in human fetal brain tissue extracts. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 2 antibody

WB Suggested Anti-ADCY2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: 293T cell lysate.There is BioGPS gene expression data showing that ADCY2 is expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 2 Control Peptide

Adenylate cyclase type 2
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 2 antibody

Western blot with AP10183PU-N (1:1000). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 2 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ADCY2 antibody (C-term)(Cat.#AP12381PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Adenylate cyclase type 2 (Center) antibody

ADCY2 Antibody (Center) (Cat. #AP50086PU-N) western blot analysis in Jurkat cell line lysates (35 µg/lane).This demonstrates the ADCY2 antibody detected the ADCY2 protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Adenylate cyclase type 2 antibody

Adenylate cyclase type 2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Adenylate cyclase type 2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between GNAS and ADCY2. HeLa cells were stained with anti-GNAS rabbit purified polyclonal 1:1200 and anti-ADCY2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2b 1D4 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Adenylate cyclase type 2 antibody

Western blot analysis of ADCY2 polyclonal antibody ( Cat # PAB2595 ) in Jurkat cell line lysates ( 35 µg/lane ) . ADCY2 ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Adenylate cyclase type 2 antibody

Adenylate cyclase type 2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Adenylate cyclase type 2 antibody

Western  Blot:  Adenylate Cyclase 2 Antibody [NBP1-33659] – Western blot analysis of Adenylate Cyclase 2 on IMR32 lysates using NBP1-33659 at a dilution of 1:1000. 30ug whole cell lysate loaded on 7.5% SDS PAGE gel. Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Adenylate cyclase type 2 antibody

Immunohistochemistry-Paraffin: Adenylate Cyclase 2 Antibody [NBP1-90280] Immunohistochemical staining of human stomach shows strong cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Adenylate cyclase type 2 antibody

Immunohistochemistry-Paraffin: Adenylate Cyclase 2 Antibody [NBP1-90281] Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Adenylate cyclase type 2

Adenylate cyclase type 2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Adenylate cyclase type 2

Adenylate cyclase type 2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

15 Item(s)

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