Adenylate cyclase type 2 antibody

Principal name

Adenylate cyclase type 2 antibody

Alternative names for Adenylate cyclase type 2 antibody

ADCY2, KIAA1060, Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2

SwissProt ID

P26769 (Rat), Q08462 (Human), Q80TL1 (Mouse)

Gene ID

108 (ADCY2), 81636 (Adcy2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Adenylate cyclase type 2 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gsa to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 2 antibody

  Rabbit anti-ADCY2 polyclonal antibody  
Western blot analysis of human fetal brain tissue extracts with anti-ADCY2 antibody (1:500). This antibody identified a band of ~125kDa in human fetal brain tissue extracts. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 2 antibody

  Rabbit Polyclonal Anti-ADCY2 Antibody  
WB Suggested Anti-ADCY2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: 293T cell lysate.There is BioGPS gene expression data showing that ADCY2 is expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 2 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ADCY2 antibody (C-term)(Cat.#AP12381PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Adenylate cyclase type 2 (Center) antibody

ADCY2 Antibody (Center) (Cat. #AP50086PU-N) western blot analysis in Jurkat cell line lysates (35 µg/lane).This demonstrates the ADCY2 antibody detected the ADCY2 protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ADCY2 (mGFP-tagged) - Human adenylate cyclase 2 (brain) (ADCY2), 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY2 (mGFP-tagged) - Human adenylate cyclase 2 (brain) (ADCY2), 200 uL, >10^7 TU/mL  
200 µl / €2,200.00
  OriGene Technologies, Inc.

Lenti ORF particles, ADCY2 (Myc-DDK tagged) - Human adenylate cyclase 2 (brain) (ADCY2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY2 (Myc-DDK tagged) - Human adenylate cyclase 2 (brain) (ADCY2) , 200 uL, >10^7 TU/mL  
200 µl / €1,980.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Adcy2 (GFP-tagged ORF) - Rat adenylate cyclase 2 (brain) (Adcy2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adcy2 (GFP-tagged ORF) - Rat adenylate cyclase 2 (brain) (Adcy2), 200 uL, >10^7 TU/mL  
200 µl / €2,260.00
  OriGene Technologies, Inc.

Lenti ORF particles, Adcy2 (Myc-DDK-tagged ORF) - Rat adenylate cyclase 2 (brain) (Adcy2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adcy2 (Myc-DDK-tagged ORF) - Rat adenylate cyclase 2 (brain) (Adcy2), 200 uL, >10^7 TU/mL  
200 µl / €2,037.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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