Adenylate cyclase type 3 antibody

Principal name

Adenylate cyclase type 3 antibody

Alternative names for Adenylate cyclase type 3 antibody

ADCY3, KIAA0511, Adenylate cyclase type III, ATP pyrophosphate-lyase 3, Adenylyl cyclase 3

SwissProt ID

O60266 (Human), P21932 (Rat), Q8VHH7 (Mouse)

Gene ID

109 (ADCY3), 64508 (Adcy3)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)

Background of Adenylate cyclase type 3 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interactions of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gsa to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 3 antibody

Western Blot: Adenylate Cyclase 3 Antibody - Western blot of rat olfactory epithelium (OE) and frontal cortex (FC). The antibody stains a band at about 200kDa in olfactory epithelium which is rich in cilia. Fewer cilia are found in frontal cortex, and the protein is less heavily glycosylated, and a less prominent band is seen at about 160kDa. Data generated in the laboratory of Matt Sarkisian in the University of Florida. Rabbit Purified Hu, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 3 Control Peptide

Adenylate cyclase type 3
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 3 antibody

Adenylate cyclase type 3 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 3 (C-term) antibody

Immunofluorescence of cultured rat neurons and glia showing strong staining of neuronal cilia using our anti-Adenylate Cyclase III Antibody (red) and axonal and dendritic staining of Alpha II Spectrin Antibody (Cat.-No AM32996PU-N) (green) revealing the submembraneous cytoskeleton and DNA (blue). Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Adenylate cyclase type 3 antibody

Adenylate cyclase type 3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Adenylate cyclase type 3

Adenylate cyclase type 3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Adenylate cyclase type 3

Adenylate cyclase type 3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

7 Item(s)

per page
  • LinkedIn