Adenylate cyclase type 4 antibody

Principal name

Adenylate cyclase type 4 antibody

Alternative names for Adenylate cyclase type 4 antibody

Adenylate cyclase type IV,Adenylyl cyclase 4, ADCY4, ATP pyrophosphate-lyase 4

SwissProt ID

P26770 (Rat), Q8NFM4 (Human), Q91WF3 (Mouse)

Gene ID

196883 (ADCY4), 104110 (Adcy4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Adenylate cyclase type 4 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (10). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCrs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that in turn can regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi hetero-trimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of of GDP to GTP that is bound to G protein. The GTP binding reduces the affinity of Gs(a) to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes. Adenylate cyclase Type 4 is located on chromosome type 11.

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 4 antibody

  Rabbit polyclonal anti-ADCY4 antibody  
Western blot analysis of extracts from Jurkat cells, using ADCY4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 4 antibody

  Anti-ADCY4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and liver cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using ADCY4 antibody at dilution 1/45, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 4 antibody

  Anti-ADCY4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using ADCY4 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 4 antibody

Western blot (WB) analysis of A Cyclase IV antibody (Cat.-No.: AP01506PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Adenylate cyclase type 4 (Center) antibody

Western blot analysis of ADCY4 Antibody (Center)(Cat. #AP50087PU-N) in Hela cell line lysates (35 µg/lane). ADCY4 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Adenylate cyclase type 4 antibody

Western blot analysis of extracts from Jurkat cells, using ADCY4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

Adenylate cyclase type 4 antibody

Western blot analysis of extracts from Jurkat cells, using ADCY4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ADCY4 - human gene knockout kit via CRISPR

ADCY4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ADCY4 - human gene knockout kit via CRISPR

ADCY4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADCY4 - human gene knockout kit via CRISPR

ADCY4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ADCY4 - human gene knockout kit via CRISPR

ADCY4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy4 - mouse gene knockout kit via CRISPR

Adcy4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Adcy4 - mouse gene knockout kit via CRISPR

Adcy4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy4 - mouse gene knockout kit via CRISPR

Adcy4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Adcy4 - mouse gene knockout kit via CRISPR

Adcy4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ADCY4 (mGFP-tagged)-Human adenylate cyclase 4 (ADCY4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY4 (mGFP-tagged)-Human adenylate cyclase 4 (ADCY4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, ADCY4 (Myc-DDK-tagged)-Human adenylate cyclase 4 (ADCY4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ADCY4 (Myc-DDK-tagged)-Human adenylate cyclase 4 (ADCY4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,950.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Adcy4 (Myc-DDK-tagged) - Mouse adenylate cyclase 4 (Adcy4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Adcy4 (Myc-DDK-tagged) - Mouse adenylate cyclase 4 (Adcy4), 200 uL, >10^7 TU/mL  
200 µl / €1,690.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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