Adenylate cyclase type 8 antibody

Principal name

Adenylate cyclase type 8 antibody

Alternative names for Adenylate cyclase type 8 antibody

ADCY8, Adenylate cyclase type VIII, ATP pyrophosphate-lyase 8, Adenylyl cyclase 8

SwissProt ID

P40145 (Human), P40146 (Rat), P97490 (Mouse)

Gene ID

114 (ADCY8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Adenylate cyclase type 8 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gs to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes. The Ca2+/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addiction and persistent pain. PAC8 has been linked to interleukin induced cell differentiation of vascular smooth muscle in to secretory cells (6).

General readings

1. G-proteins signal transduction & disease Ed. Milligan G and Wakeman M. Pub. Acad. Press, Scotland, UK 1992.
2. Tang W. J and Gilman A. G. Adenyl Cyclases, Cell 70, 869-872; 1992.
3. Taussing R., Tang W., et. Al., J. Biol. Chemistry 269; 6093-6100; 1994.
4. Gilman A. G. 1987; Ann. Rev. Biochem. 56; 615-649.
5. Bourne H. R., Sanders. D. A., McCormick F., Nature 1990; 348; 125-132.
6. Clement N, Glorian M, Raymondjean M, Andreani M, Limon I. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2
receptors 3 due to the emerging expression of adenylyl cyclase 8 . J Cell Physiol. 2006 Sep;208(3):495-505.

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 8 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 8 Control Peptide

Adenylate cyclase type 8
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 8 antibody

Adenylate cyclase type 8 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 8 antibody

Adenylate cyclase type 8 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Adenylate cyclase type 8 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

Adenylate cyclase type 8 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

Adenylate cyclase type 8 antibody

Human 721_B; WB Suggested Anti-ADCY8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: 721_B cell lysate; ADCY8 antibody - middle region (ARP45047_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Adenylate cyclase type 8 antibody

Adenylate cyclase type 8 Rabbit IgG Serum Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

Adenylate cyclase type 8 antibody

Adenylate cyclase type 8 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €360.00
  Novus Biologicals Inc.

Adenylate cyclase type 8 antibody

Adenylate cyclase type 8 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €290.00
  Novus Biologicals Inc.

Adenylate cyclase type 8 antibody

Western Blot: adenylate cyclase 8 Antibody [NBP1-59027] - This Anti-ADCY8 antibody was used in Western Blot of 721_B tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Adenylate cyclase type 8 antibody

Immunohistochemistry-Paraffin: Adenylate Cyclase 8 Antibody [NBP1-90278] Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Adenylate cyclase type 8

Adenylate cyclase type 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Adenylate cyclase type 8

Adenylate cyclase type 8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

14 Item(s)

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