Adenylate cyclase type 9 antibody

Principal name

Adenylate cyclase type 9 antibody

Alternative names for Adenylate cyclase type 9 antibody

ADCY9, KIAA0520, Adenylate cyclase type IX, ATP pyrophosphate-lyase 9, Adenylyl cyclase 9

SwissProt ID

O60503 (Human), P51830 (Mouse), Q9DGG6 (Chick)

Gene ID

115 (ADCY9)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Adenylate cyclase type 9 antibody

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gsa to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adenylate cyclase type 9 antibody

Western blot analysis of A549 cell lysate with anti-ADCY9 antibody (1:500). This antibody identified a band of ~110kDa in A549 cell lysate (predicted molecular weight: 150kDa). Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Adenylate cyclase type 9 Control Peptide

Adenylate cyclase type 9
0.1 mg / €250.00
  Acris Antibodies GmbH

Adenylate cyclase type 9 antibody

Adenylate cyclase type 9 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Adenylate cyclase type 9 antibody

Adenylate cyclase type 9 Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

Adenylate cyclase type 9 antibody

Adenylate cyclase type 9 Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

Adenylate cyclase type 9 antibody

Immunohistochemical analysis of Adenylate Cyclase 9 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Adenylate cyclase type 9 antibody

Immunohistochemical analysis of Adenylate Cyclase 9 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Adenylate cyclase type 9 antibody

Immunohistochemical analysis of Adenylate Cyclase 9 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

8 Item(s)

per page
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