AFAP1L2 antibody

Principal name

AFAP1L2 antibody

Alternative names for AFAP1L2 antibody

AFAP1-like protein 2, KIAA1914, XB130, Actin filament-associated protein 1-like 2

SwissProt ID

Q17R10 (Bovin), Q5DTU0 (Mouse), Q8N4X5 (Human)

Gene ID

84632 (AFAP1L2), 226250 (Afap1l2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of AFAP1L2 antibody

AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AFAP1L2 antibody

  Rabbit Polyclonal AFAP1L2 Antibody  
Western blot analysis of AFAP1L2 in mouse liver tissue lysate with AFAP1L2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AFAP1L2 antibody

  Rabbit Polyclonal Anti-AFAP1L2 Antibody  
WB Suggested Anti-AFAP1L2 Antibody; Titration: 1.0 ug/ml; Positive Control: ACHN Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AFAP1L2 (C-term) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

AFAP1L2 - human gene knockout kit via CRISPR

AFAP1L2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AFAP1L2 - human gene knockout kit via CRISPR

AFAP1L2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AFAP1L2 - human gene knockout kit via CRISPR

AFAP1L2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AFAP1L2 - human gene knockout kit via CRISPR

AFAP1L2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Afap1l2 - mouse gene knockout kit via CRISPR

Afap1l2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Afap1l2 - mouse gene knockout kit via CRISPR

Afap1l2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Afap1l2 - mouse gene knockout kit via CRISPR

Afap1l2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Afap1l2 - mouse gene knockout kit via CRISPR

Afap1l2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AFAP1L2 (transcript variant 2)

  Recombinant protein of human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2  
AFAP1L2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AFAP1L2 (transcript variant 1)

  Recombinant protein of human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 1  
AFAP1L2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

AFAP1L2 overexpression lysate

AFAP1L2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AFAP1L2 (mGFP-tagged) - Human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, AFAP1L2 (mGFP-tagged) - Human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, AFAP1L2 (Myc-DDK tagged) - Human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AFAP1L2 (Myc-DDK tagged) - Human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,470.00
  OriGene Technologies, Inc.

Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,250.00
  OriGene Technologies, Inc.

Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

20 Item(s)

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