AFAP1L2 antibody

Principal name

AFAP1L2 antibody

Alternative names for AFAP1L2 antibody

AFAP1-like protein 2, KIAA1914, XB130, Actin filament-associated protein 1-like 2

SwissProt ID

Q17R10 (Bovin), Q5DTU0 (Mouse), Q8N4X5 (Human)

Gene ID

84632 (AFAP1L2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of AFAP1L2 antibody

AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AFAP1L2 antibody

Western blot analysis of AFAP1L2 in mouse liver tissue lysate with AFAP1L2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AFAP1L2 antibody

WB Suggested Anti-AFAP1L2 Antibody; Titration: 1.0 ug/ml; Positive Control: ACHN Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AFAP1L2 (C-term) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AFAP1L2 Control Peptide

AFAP1L2
50 µg / €160.00
  Acris Antibodies GmbH

AFAP1L2 (N-term) antibody

Human ACHN; WB Suggested Anti-AFAP1L2 Antibody. . Titration: 1.0 ug/ml. . Positive Control: ACHN Whole Cell; AFAP1L2 antibody - N-terminal region (ARP60221_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

AFAP1L2 antibody

AFAP1L2 Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

AFAP1L2 antibody

Immunohistochemistry-Paraffin: AFAP1L2 Antibody [NBP1-77358] - Human liver tissue with AFAP1L2 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

AFAP1L2 antibody

Immunohistochemistry-Paraffin: AFAP1L2 Antibody [NBP1-84859] - Immunohistochemical staining of human seminal vesicle shows strong cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AFAP1L2 (transcript variant 2)

AFAP1L2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AFAP1L2 (transcript variant 1)

AFAP1L2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AFAP1L2

AFAP1L2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

AFAP1L2 overexpression lysate

AFAP1L2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

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