AGAP2 / CENTG1 antibody

Principal name

AGAP2 / CENTG1 antibody

Alternative names for AGAP2 / CENTG1 antibody

Centaurin-gamma-1, KIAA0167, GGAP2, PIKE, Arf-GAP GTPase ANK repeat and PH domain-containing protein 2, Phosphatidylinositol-3-kinase enhancer, GTP-binding and GTPase-activating protein 2

SwissProt ID

Q3UHD9 (Mouse), Q8CGU4 (Rat), Q99490 (Human)

Gene ID

116986 (AGAP2), 216439 (Agap2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of AGAP2 / CENTG1 antibody

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity (1). PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1 (reviewed in 2). The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis (3). Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes (4). In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AGAP2 / CENTG1 antibody

  Goat Anti-CENTG1 / PIKE Antibody  
TA305917 (0.3ug/ml) staining of Human Amygdala lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AGAP2 / CENTG1 (C-term) antibody

  Rabbit Polyclonal PIKE Antibody  
Western blot analysis of PIKE in mouse brain cell lysates with PIKE antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AGAP2 / CENTG1 (1-836) antibody

  Rabbit polyclonal anti-AGAP2 antibody  
Western blot using Protein A purified anti-AGAP2 antibody shows detection of AGAP2 recombinant protein in transfected HEK293 cell lysates. No specific band staining is noted in mock transfected cell lysates (empty vector). The membrane was probed with the primary antibody diluted to 1:10,000. Personal Communication, Paul Randazzo, CCR-NCI, Bethesda, MD. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

AGAP2 / CENTG1 antibody

  Rabbit Polyclonal Anti-CENTG1 Antibody  
WB Suggested Anti-CENTG1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AGAP2 / CENTG1 (C-term) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AGAP2 / CENTG1 (1-836) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AGAP2 / CENTG1 (C-term) antibody

CENTG1 Antibody (C-term) (Cat. #AP50861PU-N) western blot analysis in mouse brain tissue lysates (35µg/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AGAP2 / CENTG1 (Isoform 2) antibody

AGAP2 / CENTG1 Rabbit Serum Hu E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

AGAP2 - human gene knockout kit via CRISPR

AGAP2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AGAP2 - human gene knockout kit via CRISPR

AGAP2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGAP2 - human gene knockout kit via CRISPR

AGAP2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGAP2 - human gene knockout kit via CRISPR

AGAP2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agap2 - mouse gene knockout kit via CRISPR

Agap2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Agap2 - mouse gene knockout kit via CRISPR

Agap2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agap2 - mouse gene knockout kit via CRISPR

Agap2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agap2 - mouse gene knockout kit via CRISPR

Agap2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AGAP2 (mGFP-tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, AGAP2 (mGFP-tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,350.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGAP2 (mGFP-tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, AGAP2 (mGFP-tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGAP2 (Myc-DDK tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AGAP2 (Myc-DDK tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €2,120.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGAP2 (Myc-DDK tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AGAP2 (Myc-DDK tagged) - Human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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