Agouti-related protein / AGRP antibody

Principal name

Agouti-related protein / AGRP antibody

Alternative names for Agouti-related protein / AGRP antibody

AGRT, ART

SwissProt ID

O00253 (Human), P56413 (Bovin), P56473 (Mouse), Q9TU18 (Pig)

Gene ID

181 (AGRP), 11604 (Agrp)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Goat, Rat, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Agouti-related protein / AGRP antibody

Agouti-related protein is an endogenous antagonist of hypothalamic alpha-melanocortin receptors MC3R and MC4R with potent orexigenic activity. Although a complete deletion of the AGRP gene does not produce any significant metabolic phenotypes, reduction in AGRP expression by RNA interference is associated with increased metabolic rate along with reduced weight gain. In hypothalamus, it is produced by neurons in the medial portion of arcuate nucleus, which produce also the potent orexigenic peptide Neuropeptide Y (NP-Y). Another site of central AGRP production is the hypothalamic nucleus. AGRP encompasses 132 amino acid residues and its alpha-melanocortin inhibiting activity results in a 34 amino acid cystine knot domain within the C-terminal (87-132) portion of the protein. Both AGRP and NP-Y expression was shown to be supressed by leptin. Central administration of AGRP induces hyperphagia and increased gain in body weight in rodents, but may also exert metabolic effects even when hyperphagia is prevented. In the absence of hyperphagia, intracerebralventricular administration of AGRP caused significant increases in plasma leptin and insulin concentrations (two-fold and 1.5-fold, respectively) and fat pad mass. In the perifery, AGRP mRNA was found in adrenal glands, lung, testis, ovary, skeletal muscle and adipose tissue in humans or rodents. In the adrenals, it was shown that AGRP antagonizes glucosteroid production mediated by MC4R. AGRP could then modulate locally the functions of some peripheral tissues such as adrenals. In human and rat serum, detectable levels of AGRP-like activity were reported in the lower picogram range. The serum AGRP levels were elevated in obese humans compared to lean controls and increased with fasting in rats.
Total 128 AA. MW: 14.4 kDa (calculated). N-Terminal His-tag, 16 extra AA (highlighted).

General readings

Xiao E, Xia-Zhang L, et al.(2003). Endocrinology. 144(5):1736-41.Creemers JW, Pritchard LE, et al. (2006). Endocrinology. 147(4):1621-31.

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Agouti-related protein / AGRP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and gastric cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using AGRP antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Agouti-related protein / AGRP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and liver cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using AGRP antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Agouti-related protein / AGRP (C-term) antibody

AP32076PU-N AGRP Antibody staining of PFA-perfused cryosection of Human Hypothalamus at 0.05 µg/ml. Antigen retrieval with citrate buffer pH 6 at 80°C for 30min, HRP-staining with Ni-DAB after Biotin-SP-anti-goat amplification. Data obtained by Prof. Erik Hrabovszky, Inst, Exp, Med., Budapest, Hungary. Goat Aff - Purified Can, Hu, Por C, E
0.1 mg / €340.00
  Acris Antibodies GmbH

Agouti-related protein / AGRP antibody

Agouti-related protein / AGRP Rabbit Aff - Purified Hu C, E, WB
50 µg / €370.00
  Acris Antibodies GmbH

Agouti-related protein / AGRP antibody

Agouti-related protein / AGRP Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Agouti-related protein / AGRP antibody

Agouti-related protein / AGRP Goat Aff - Purified Ms, Rt C, E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

Agouti-related protein / AGRP antibody

Agouti-related protein / AGRP Goat Aff - Purified Hu C, E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

Agouti-related protein / AGRP antibody

Agouti-related Protein (AgRP) expression was detected in a cryostat section of mouse brain. The tissue was stained using the NorthernLights-637 anti-rat IgG secondary antibody ( red) and counterstained with FluoroNissl™ Green (green). Rat IgG2b 104138 Purified Ms C, E, WB
0.5 mg / €410.00
  Neuromics Antibodies

Agouti-related protein / AGRP antibody

Immunohistochemistry-Paraffin: AGRP Antibody [NBP1-89203] Immunohistochemical staining of human breast shows strong cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Agouti-related protein / AGRP (transcript variant 1)

Agouti-related protein / AGRP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Agouti-related protein / AGRP (21-132, His-tag)

Agouti-related protein / AGRP Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

Agouti-related protein / AGRP (21-132, His-tag)

Agouti-related protein / AGRP Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

Agouti-related protein / AGRP

12% SDS-PAGE separation of Human A GRP
1. M.W. marker - 14, 21, 31, 45, 66, 97 kDa
2. reduced and heated sample, 5µg/lane
3. non-reduced and non-heated sample, 5µg/lane Human Purified > 95 % >95% E. coli
0.1 mg / €470.00
  Acris Antibodies GmbH

Agouti-related protein / AGRP

Agouti-related protein / AGRP Human Purified > 90 % Insect cells
2 µg / €180.00
  Neuromics Antibodies

ELISA Kits

Catalog No.    

OmniKine™ Human AgRP ELISA Kit

OmniKine™ Human AgRP ELISA Kit  
96 Tests / €410.00
  Assay Biotech

15 Item(s)

per page
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